Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response

World Journal of Gastroenterology : WJG
Zhu-Fu QuanJie-Shou Li

Abstract

To study the effects of glutamine (Gln) on the change of intestinal permeability and its relationship to systemic inflammatory response in early abdominal postoperative patients. A prospective, randomized, double-blind and controlled trial was taken. Twenty patients undergoing abdominal surgery were randomized into Gln group (oral administration of glutamine, 30 g/d, for 7 d, n=10) and placebo group (oral administration of placebo, 30 g/d, for 7 d, n=10). Temperatures and heart rates of all patients were daily recorded. White blood cell counts(WBC) and biochemical variables were measured before operation and 4 and 7 d after drug administration. Serum concentrations of glutamine, endotoxin, diamine oxidase and malondialdehyde and urine lactulose/mannito (L/M) ratio were measured before and 7 d after drug administration. The patients in the 2 groups were comparable prior to drug administration. Serum Gln concentration was significantly decreased in the placebo group and increased in the Gln group 7 d after drug administration. Urine L/M ratio was significantly increased in the placebo group and decreased in the Gln group. The serum concentration of endotoxin, diamine oxidase and malondialdehyde was significantly decreased in the ...Continue Reading

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Citations

May 27, 2014·Neuroscience and Biobehavioral Reviews·Steven MoylanMichael Maes
Feb 3, 2016·Molecular Nutrition & Food Research·Naveena B JanakiramChinthalapally V Rao
Mar 17, 2005·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Carla R HeiserMichael P Dube
Mar 13, 2014·Journal of Neurotrauma·Angus G Scrimgeour, Michelle L Condlin
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Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jacqueline Carvalho-PeixotoLuiz-Claudio Cameron
Aug 9, 2007·The American Journal of Clinical Nutrition·Elizabeth A WilliamsPeter G Lunn

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