PMID: 8583290Nov 1, 1995Paper

Effect of glutamine-supplemented elemental diet on mucosal adaptation following bowel resection in rats

Journal of Pediatric Gastroenterology and Nutrition
S MichailJ A Vanderhoof

Abstract

Glutamine is the major fuel for enterocytes and prevents mucosal atrophy in certain animal models. Previous studies in our laboratory have failed to show a trophic effect of glutamine on the small-bowel mucosa following massive resection when added to a chow diet. However, the complexity of the chow diet might potentially interfere with the adequate evaluation of the trophic effect of a single agent such as glutamine. This study was therefore designed to determine whether the addition of glutamine to an elemental diet would augment mucosal adaptation following massive small intestinal resection in a rat model. Male Sprague-Dawley rats were divided into two dietary groups, one receiving an amino acid-based pediatric elemental diet supplemented with 2% glutamine, and the other receiving the diet supplemented with 2% glucose. One half of the animals in each dietary group received 80% jejunoileal resection, and the remainder were sham operated. Fifteen days postsurgery, mucosal weight, DNA, protein, and sucrase activities were determined in both the proximal and the distal small intestine. While both groups of resected animals developed marked increases in all parameters of adaptation, the glutamine-supplemented group did not diffe...Continue Reading

Citations

Aug 1, 2002·Current Gastroenterology Reports·Palle Bekker Jeppesen, Per Brobech Mortensen
May 4, 1999·The International Journal of Biochemistry & Cell Biology·R McCauleyJ C Hall
Sep 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·J A VanderhoofT E Adrian
Mar 8, 2005·Postgraduate Medical Journal·A R WealeP A Lear
Mar 11, 2003·Annual Review of Nutrition·Thomas R ZieglerDean P Jones
Mar 4, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Kelly A Tappenden
Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·R McCauleyJ Hall
Nov 26, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·T R ZieglerL M Leader
Jun 20, 2002·ANZ Journal of Surgery·Carlo F M WeltersErik Heineman
Jul 6, 2004·The American Journal of Gastroenterology·John K DiBaiseJon A Vanderhoof
Dec 16, 2005·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Jason J Cisler, Alan L Buchman
Feb 8, 2002·World Journal of Gastroenterology : WJG·Cameron F E PlatellJohn C Hall
Dec 9, 1998·The American Journal of Physiology·J QuanS E Fleming
Mar 29, 2002·Clinics in Perinatology·Douglas G Burrin, Barbara Stoll

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