PMID: 6112326Apr 25, 1981Paper

Effect of gluten-free diet on an immunological assay for coeliac disease

Lancet
A AshkenaziZ T Handzel

Abstract

The leucocyte migration inhibition factor (LIF) test for the presence of lymphocytes sensitised to gluten was evaluated over the past 4 years in patients with coeliac disease and correlated with the presence of gluten in the patients' diet. 149 LIF tests were done in 66 coeliac patients, 35 of whom were on a normal diet. However, 7 of 8 clinically and histologically diagnosed cases of coeliac disease who were LIF negative when first tested on a normal diet became LIF positive when placed on a gluten-free diet, so that 94% of patients with coeliac disease were LIF positive. On a prolonged gluten-free diet about 50% of LIF-positive cases became negative. The response to the LIF test seems to be related to gluten intake, with higher LIF values when the patient is taking gluten, and lower values when gluten is eliminated from the diet.

Citations

May 1, 1982·European Journal of Pediatrics·A AshkenaziN Barzilai
Nov 1, 1984·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·H WieserA Ashkenazi
Jan 1, 1982·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·H WieserD Idar
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T T MacDonald
May 1, 1983·The Journal of Pediatrics·E P McCarty, O L Frick
May 1, 1983·Scandinavian Journal of Gastroenterology·A F KilanderA Tarkowski

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