Effect of glyceryl trinitrate on coronary and systemic hemodynamics in man

The American Journal of Medicine
C R ContiJ B Conti

Abstract

The effects of sublingual and intracoronary nitrates on coronary artery diameter were evaluated in five separate experiments in man. The first three are concerned with sublingual nitrates and the last two with intracoronary nitrates. The data obtained indicate that (1) administration of a fixed dose sublingual nitrate results in an increase in percent coronary artery stenosis compared with control measurements; (2) small doses of sublingual nitrates can dilate coronary arteries without a significant reduction in systemic arterial pressure or increase in heart rate; (3) the magnitude of percent coronary artery dilation after a fixed dose of sublingual nitrate is inversely related to the size of the coronary artery, that is, the smaller the coronary artery diameter the greater the relative dilation after administration of sublingual nitrate; (4) fixed dose sublingual nitrate often dilated coronary stenoses, but the more narrow stenoses were less likely to dilate; (5) the optimal dose of intracoronary nitrate required to produce maximal or near maximal coronary dilation without clinically important systemic hemodynamic effects is in the range of 200 micrograms; (6) intracoronary nitrate is a more potent coronary artery dilator tha...Continue Reading

Citations

Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Stephanie Li Mei TayLai Wah Chan
Jul 1, 1985·American Heart Journal·J Abrams
May 8, 2002·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·James S Tweddell, George M Hoffman
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Jul 14, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rebecca PerryArduino A Mangoni
Sep 29, 2006·The Journal of the Acoustical Society of America·Daniel Rouseff, Dajun Tang
Jun 17, 2010·The Journal of the Acoustical Society of America·Daniel Rouseff, Dajun Tang
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·K Luomanmäki

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