Effect of glycine on tissue fatty acid composition in an experimental model of alcohol-induced hepatotoxicity

Clinical and Experimental Pharmacology & Physiology
Rajagopal Senthilkumar, Namasivayam Nalini

Abstract

1. The aim of the present study was to investigate the effect of the administration of glycine, a non-essential amino acid, on blood alcohol levels and tissue fatty acid composition in experimental rats. 2. Liver cell damage was induced by the administration of ethanol (7.9 g/kg bodyweight) for 30 days by intragastric intubation. Control rats were given isocaloric glucose solution. Glycine was subsequently administered at a dose of 0.6 g/kg bodyweight every day by intragastric intubation for the next 30 days. 3. Feeding alcohol significantly elevated the activities of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatases (ALP) and gamma-glutamyl transpeptidase (GGT) and altered the liver and brain fatty acid composition compared with control rats. Subsequently, glycine supplementation to alcohol-fed rats significantly lowered the activities of serum AST, ALT, ALP, GGT and normalized the liver and brain fatty acid composition compared with untreated alcohol-fed rats. 4. Thus, the present study demonstrates that oral administration of glycine confers a significant protective effect against alcohol-induced hepatotoxicity by virtue of its ability to optimize the activities of serum AST, ALT, ALP and ...Continue Reading

References

Jan 1, 1985·Methods in Enzymology·S S Tate, A Meister
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Sanchis, C Guerri
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·D F Horrobin
Jun 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·K FalholtW Falholt
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Warner, J A Gustafsson
Jan 5, 1996·The Journal of Biological Chemistry·D Mengin-Lecreulx, J van Heijenoort
Jan 1, 1996·The American Journal of Physiology·K AmslerJ L Chen
Sep 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A R WaladkhaniC Bode
Jul 2, 1998·Biochemical and Biophysical Research Communications·Q HeN H Ansari
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F StachlewitzR G Thurman
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GalliD Crabb
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M WheelerR G Thurman
Apr 12, 2000·Journal of Gastroenterology and Hepatology·N EnomotoR G Thurman
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M Parsons
Jun 21, 2002·Asia Pacific Journal of Clinical Nutrition·Rajagopal Senthil KumarNamasivayam Nalini
Jul 2, 2003·The Journal of Pharmacy and Pharmacology·Akihiko UrayamaRyohei Kimura
Sep 2, 2003·The Journal of Nutritional Biochemistry·Senthil Kumar RajagopalNalini Namasivayam
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL

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Citations

Mar 25, 2017·Oxidative Medicine and Cellular Longevity·Meerza Abdul RazakSenthilkumar Rajagopal

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