Effect of glycogen loading on skeletal muscle cross-sectional area and T2 relaxation time

Acta Physiologica Scandinavica
A T NygrenL Kaijser

Abstract

This study was performed to investigate if glycogen loading of skeletal muscles, by binding water, would effect the cross-sectional area (CSA) and if an altered water content would alter the transverse relaxation time (T2) measured by magnetic resonance imaging (MRI). Five healthy volunteers participated in a programme with 4 days of extremely carbohydrate-restricted meals followed by 4 days of extremely high carbohydrate intake. The CSA and T2 of thigh and calf muscles were related to the intramuscular glycogen content evaluated at days 4 and 8. An increase in glycogen content from 281 to 634 mmol kg(-1) dry wt increased the CSA of the vastus muscles by 3.5% from 78 +/- 11 to 80 +/- 12 cm2 and the thigh circumference by 2.5% from 146 +/- 20 to 150 23 cm2. Calf circumference increased non-significantly by 4% from 78 +/- 15 to 82 +/- 19 cm2. Mono-exponential T2 decreased in m. tibialis anterior from 27.8 +/- 1.2 to 26.9 +/- 1.7 ms, did not change in m. vastus lateralis 26.5 +/- 1.9 ms/26.6 +/- 1.3 ms or in m. gastrocnemius 29.5 +/- 1.0 ms/29.8 +/- 1.9 ms. Glycogen loading increased the signal intensity mainly at different echo times (TE) 15 and 30 ms. The study shows that increased glycogen filling in the muscles increases muscl...Continue Reading

References

Mar 1, 1976·Acta Physiologica Scandinavica·B SaltinD Gollnick
Jul 1, 1977·Acta Physiologica Scandinavica·E Jansson, L Kaijser
May 1, 1976·Progress in Cardiovascular Diseases·J O Holloszy
Jan 1, 1973·Journal of Applied Physiology·P D GollnickR E Shepherd
May 1, 1967·Analytical Biochemistry·D W SchulzO H Lowry
Aug 28, 1972·JAMA : the Journal of the American Medical Association·J Bergström, E Hultman
May 1, 1983·The Journal of Physiology·R J MaughanJ Weir
Jul 1, 1993·Acta Physiologica Scandinavica·M EsbjörnssonL Kaijser
Sep 18, 1997·Journal of Applied Physiology·R C HicknerJ O Holloszy
Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G SaabG D Marsh
Jul 20, 1999·Journal of Applied Physiology·J S GreiweJ O Holloszy
Jul 6, 2000·European Journal of Applied Physiology·A T NygrenL Kaijser

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Citations

Jul 12, 2002·NMR in Biomedicine
Apr 25, 2007·Journal of Sports Sciences·Ronald J MaughanJohn B Leiper
Aug 21, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew P HarberScott Trappe
May 10, 2008·Scandinavian Journal of Medicine & Science in Sports·M WernbomT Raastad
Jul 6, 2014·Journal of Sports Sciences·Lawrence E ArmstrongKeith H Williamson
May 1, 2007·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Ferdinand von WaldenPer A Tesch
Dec 24, 2015·Medicine and Science in Sports and Exercise·Ricardo Mora-RodríguezJorn W Helge
Dec 9, 2004·Multiple Sclerosis : Clinical and Laboratory Research·L J WhiteK Vandenborne
Apr 15, 2017·Medicine and Science in Sports and Exercise·Julia L BoneLouise M Burke
Aug 22, 2021·BMC Sports Science, Medicine and Rehabilitation·Emi KondoHideyuki Takahashi

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