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Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

bioRxiv

Dec 10, 2013

Joanna DembowyJames Robert Woodgett

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Abstract

Many components of Wnt/?-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3? and GSK-3?) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion ...read more

Mentioned in this Paper

Wnt Proteins
Inactivation
Mammary Epithelium
Gene Knockout Techniques
Adenosquamous Carcinoma
Protein Isoforms
Adenocarcinoma
Neoplastic Cell Transformation
Mammary Gland
Signal Transduction Pathways
7
12
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  • Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

    bioRxiv

    Dec 10, 2013

    Joanna DembowyJames Robert Woodgett

    PMID: 990001321

    DOI: 10.1101/001321

    Abstract

    Many components of Wnt/?-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3? and GSK-3?) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion ...read more

    Mentioned in this Paper

    Wnt Proteins
    Inactivation
    Mammary Epithelium
    Gene Knockout Techniques
    Adenosquamous Carcinoma
    7
    12

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