Effect of gonadectomy on the development of diabetes mellitus, hypertension, and albuminuria in the rat model

Metabolism: Clinical and Experimental
M IwaseM Fujishima

Abstract

Spontaneously hypertensive rats (SHR) given streptozotocin (STZ) neonatally developed genetic hypertension and overt hyperglycemia after the onset of puberty. In the present study, gonadectomy was performed before puberty in both males and females of this animal model. Orchidectomy suppressed the development of hypertension in vehicle-treated and STZ-treated SHR (systolic blood pressure at 11 weeks of age: 209 +/- 5 mm Hg in the intact vehicle group v 187 +/- 6 mm Hg in the orchidectomized vehicle group, P < .01; 211 +/- 14 mm Hg in the intact STZ group v 182 +/- 4 mm Hg in the orchidectomized STZ group, P < .001). Furthermore, orchidectomy ameliorated the development of overt hyperglycemia in STZ-treated SHR (nonfasting plasma glucose at 12 weeks of age: 22.1 +/- 0.7 mmol/L in the intact group v 16.1 +/- 2.4 mmol/L in the orchidectomized group, P < .05). On the other hand, orchidectomy did not affect glucose tolerance in vehicle-treated SHR, but attenuated the insulin response to an oral glucose load (P < .05). Orchidectomy significantly decreased urinary albumin excretion and kidney weight in both the vehicle and the STZ groups. Ovariectomy significantly increased body weight gain irrespective of STZ treatment. However, ovari...Continue Reading

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Citations

Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi HoshideKazuyuki Shimada
Jul 14, 2007·Endocrinology·Pascal BaratRuth Andrew
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Pascale H Lane
Dec 9, 1998·The American Journal of Physiology·L C SharkeyM J Radin
Oct 4, 2005·Advances in Chronic Kidney Disease·Pascale H Lane

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