Effect of gonadotropin-releasing hormone (GnRH) pulse frequency on serum and pituitary concentrations of luteinizing hormone and follicle-stimulating hormone, GnRH receptors, and messenger ribonucleic acid for gonadotropin subunits in cows

Endocrinology
J A VizcarraT M Nett

Abstract

Thirty-two nutritionally anestrous cows were used to determine the effect of the frequency of exogenous GnRH pulses on ovarian follicular growth, serum concentrations of LH and FSH, and concentrations of LH, FSH, GnRH receptors (GnRH-R), messenger RNA (mRNA) for GnRH-R, and mRNA for gonadotropin subunits in the pituitary. Cows were randomly assigned to one of four treatments: 2 micrograms GnRH infused (i.v.) continuously during 1 h, 2 micrograms GnRH infused during 5 min once every hour, 2 micrograms GnRH infused during 5 min once every fourth hour, or saline (control) for 13 days. Infusion of GnRH every hour increased LH concentrations in serum (P < 0.05), but FSH concentrations were not affected by GnRH infusion. Luteal activity (LA) was assessed by the presence of corpora lutea and/or serum progesterone greater than 1 ng/ml. Six of eight cows infused with GnRH every hour had LA by day 13, whereas only 25% of cows infused either continuously or with a pulse every fourth hour had LA by day 13. None of the control cows had LA during the experiment (P < 0.01). Concentrations of LH and FSH in the pituitary were significantly reduced when GnRH was infused hourly or continuously. Concentrations of common alpha and FSH beta mRNA wer...Continue Reading

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Citations

Sep 23, 2009·Endocrine Reviews·Amy E OakleyRobert A Steiner
Mar 13, 2012·Reproductive Biology and Endocrinology : RB&E·Faiqah RamzanFaiza Ramzan
Feb 4, 2006·Domestic Animal Endocrinology·N J BeijerinkH S Kooistra
Jun 29, 2005·Animal Reproduction Science·Adam J Pawson, Alan S McNeilly
Sep 28, 2001·Journal of Dairy Science·S M MacielL J Spicer
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·J de GierA C Okkens
Dec 23, 1998·Endocrine Reviews·S L Asa, S Ezzat
Apr 15, 2004·Endocrine Reviews·Robert P MillarStuart R Maudsley
Apr 24, 2013·Reproduction, Fertility, and Development·Lisa M CostelloDermot G Morris
Jan 25, 2003·Journal of Animal Science·F J WhiteG L Morgan
Mar 3, 2009·Journal of Animal Science·L N FloydR P Wettemann
Dec 4, 2019·General and Comparative Endocrinology·Romain FontaineFinn-Arne Weltzien
Dec 29, 2020·Frontiers in Endocrinology·Romain FontaineDianne M Baker
May 3, 2006·Theriogenology·Falk SchneiderCarsten Gründker

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