PMID: 4287149May 1, 1966Paper

Effect of gossypol on some oxidative respiratory enzymes

Plant Physiology
B D Myers, G O Throneberry

Abstract

Gossypol was examined in relation to its effect on certain enzymes and enzyme complexes associated with the tricarboxylic acid cycle and the electron transport system. Succinic dehydrogenase and cytochrome oxidase activity from sweet potato was completely inhibited by gossypol at 7.5 x 10(-3)m and 2.0 x 10(-3)m, respectively. Succinoxidase activity of the same preparations was fully inhibited at a lower concentration, 2.5 x 10(-4)m. This concentration did not affect either succinic dehydrogenase or cytochrome oxidase, the primary and terminal enzymes of the succinoxidase complex. The nature of the intermediate step or steps inhibited at this concentration is not yet known. Gossypol was further shown to inhibit phosphorylation at concentrations having no appreciable effect on oxidation. Inhibition in general was not reduced by increased substrate concentrations in the enzyme systems examined, with the exception of cytochrome c for cytochrome oxidase. Bovine serum albumin was partially effective in reducing gossypol inhibition, provided that it was present before enzyme exposure to gossypol.

References

May 17, 1960·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D KEILIN, T E KING
Oct 1, 1959·Archives of Biochemistry and Biophysics·C M LYMANM W SLAY

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Citations

Jan 1, 1989·The International Journal of Biochemistry·H BreitbartL Nass-Arden
May 16, 1974·Life Sciences·M B Abou-Donia, J W Dieckert
Dec 1, 1982·Archives of Andrology·W W TsoM Y Tso
Jul 1, 1984·Contraception·X N Ma, D J Back
Dec 1, 1990·Contraception·R L Johansen, H P Misra
Apr 1, 1984·Experimental and Molecular Pathology·A FloridiC De Martino
Jun 1, 1968·Journal of Phycology·R W Eppley, J L Coatsworth
Jun 1, 1982·International Journal of Andrology·W W Tso, C S Lee
Feb 1, 1982·Archives of Andrology·W W Tso, C S Lee
Aug 1, 1981·Archives of Andrology·W W Tso, C S Lee
Apr 1, 1984·International Journal of Andrology·F Tang, P Y Wong
Dec 1, 1988·Biochemical Pharmacology·R Rajpurohit, N Giridharan

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