Effect of graded nerve pressure injuries on motor function

Journal of Neurosurgery
Mika KarasawaNanae Fukushima

Abstract

The purpose of this study was to determine the minimum amount of nerve fibers required to maintain normal motor function after nerve injury in rats. The authors first confirmed that a common peroneal nerve injury caused more aggravating effects on lower limb motor function than tibial nerve injury, as assessed by the static sciatic index (SSI). Thereafter, rats were subjected to varying degrees of crush injury to the common peroneal nerve. At 48 hours after the injury, motor function was assessed using the SSI and slope-walking ability (with slope angles of 30° and 45°). The tibialis anterior muscle, a main muscle innervated by the common peroneal nerve, was removed. Muscle sections were co-labeled with neuronal class III β-tubulin polyclonal antibody to identify the presence of axons and Alexa Fluor 488-conjugated α-bungarotoxin to identify the presence of motor endplates. The evaluation of neuromuscular innervation showed a correlation between SSI scores and ratios of residual axons (rs = 0.68, p < 0.01), and there was a statistically significant difference between slope-walking ability and ratios of residual axons (p < 0.01). Moreover, the ratios of residual axons in the nerve-crushed rats with normal motor function (SSI abo...Continue Reading

References

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Aug 23, 2012·Neurological Research·Toshiro ItsuboTetsuji Moriizumi
Sep 8, 2012·Cell and Tissue Research·Leonore MenschingKirsten Haastert-Talini

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