PMID: 8954135Nov 22, 1996Paper

Effect of grafted PEG-2000 on the size and permeability of vesicles

Biochimica Et Biophysica Acta
A N Nikolova, M N Jones

Abstract

The permeability of PEG-derivatized vesicles produced by the extrusion technique (VETs) to encapsulated D-glucose has been studied. Vesicles were prepared from mixtures of dipalmitoylphosphatidylcholine (DPPC), phosphatidylinositol (PI) and dipalmitoylphosphatidylethanolamine with covalently attached poly(ethylene glycol) of molecular weight 2000 (DPPE-PEG2000). The occurrence of an irreversible temperature-induced size transition of the PEG-derivatized VETs was detected close to the temperature of the main phase transition of the predominant phospholipid component by photon correlation spectroscopy. The permeability of the vesicles towards radioactive D-glucose was studied by a method similar to the one proposed by Johnson and Bangham at 25, 37 and 50 degrees C for VETs with DPPE-PEG content from 0 to 9 mol%. A complex effect of the PEG-coverage was found with a maximum leakage in the range of the transition of the polymer from the mushroom to the brush conformation.

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Citations

Feb 1, 2006·European Biophysics Journal : EBJ·Georgi As GeorgievZdravko Lalchev
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·I SzleiferD H Thompson
Nov 22, 2015·Biochimica Et Biophysica Acta·Eugénia NogueiraArtur Cavaco-Paulo
Jan 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zohreh Amoozgar, Yoon Yeo
May 9, 2002·Biochimica Et Biophysica Acta·Nancy Dos SantosMarcel B Bally
Aug 9, 2005·Biochimica Et Biophysica Acta·Pierre SimardJean-Christophe Leroux
Nov 28, 2009·Journal of Liposome Research·Maryam AmidiEnrico Mastrobattista
Jul 17, 1999·Biochimica Et Biophysica Acta·M Kaszuba, M N Jones
Apr 25, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Navid MosallaeiBizhan Malaekeh-Nikouei
Jul 2, 2016·Pharmacological Reviews·Phatsapong YingchoncharoenDes R Richardson
May 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Michał StepniewskiAlex Bunker
Jun 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mattia MalvezziAlessio Accardi
Jan 1, 2014·Global Cardiology Science & Practice·Ibrahim M El-SherbinyMagdi H Yacoub
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Dec 18, 2007·International Journal of Pharmaceutics·Tatsuhiro Ishida, Hiroshi Kiwada
Aug 25, 2004·Biochemistry·Daniel PerssonBengt Nordén

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