PMID: 7543781Jan 1, 1995Paper

Effect of granulocyte colony-stimulating factor (G-CSF) on chemotherapy-induced oral mucositis

Surgery Today
M KatanoT Hisatsugu

Abstract

In this study, the ability of granulocyte colony-stimulating factor (G-CSF) to treat or prevent chemotherapy-induced oral mucositis in patients with advanced breast cancer was evaluated. A total of 14 patients who received intraarterial (i.a.) adriamycin (ADM) preoperatively were divided into two groups according to whether or not G-CSF was given. Thus, group A (n = 7) was given G-CSF and group B (n = 7) was not. G-CSF therapy reduced both the incidence and duration of ADM-induced oral mucositis, and a positive correlation was also seen between the incidence of mucositis and ADM-induced leukopenia (< 2,000/mm3). Group A was further divided into two subgroups according to whether G-CSF was given after or before the leukopenia had dropped below 2,000/mm3: group A-1 (n = 3) and group A-2 (n = 4), respectively. ADM-induced mucositis was observed in two of the three patients in group A-1, but in none of the four patients in group A-2. These results strongly support the idea that G-CSF can effectively treat and prevent ADM-induced oral mucositis.

References

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Citations

Jun 16, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Inger von BültzingslöwenDorothy Keefe
Nov 22, 2000·Drugs & Aging·J J KnoxR Feld
Sep 19, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Judith E Raber-DurlacherUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Sep 22, 2000·Current Review of Pain·W Carl, J Havens
Mar 20, 2002·Cancer Practice·M J DoddG Shiba
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid
Feb 23, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Richard M LoganUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Nov 29, 2017·The Cochrane Database of Systematic Reviews·Philip RileyMartin G McCabe

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