PMID: 7515635Mar 1, 1994Paper

Effect of granulocyte colony-stimulating factor on chemotherapy-induced neutropenia in children with cancer

Pediatric Hematology and Oncology
M KalmantiI Bolonaki

Abstract

We investigated the effects of recombinant granulocyte colony-stimulating factor (G-CSF) administration on duration of neutropenia, antibiotic therapy, and hospitalization days in 25 children with malignancies (Group A: 12 leukemia and lymphoma; Group B: 13 tumors) who were undergoing chemotherapy. We compared the effect of G-CSF with a control group of 21 children with equivalent diseases and chemotherapy that did not receive G-CSF treatment. All 25 children received 5 micrograms/kg/day of G-CSF at the end of chemotherapy courses when absolute neutrophil counts were < or = 1000/mm3. The effect of G-CSF on median neutrophil profiles, antibiotic therapy, and hospitalization days was studied for both groups at the 1st and 4th cycle of chemotherapy. During both cycles, children who received G-CSF showed a faster rise of absolute neutrophil count (P < 0.001) and fewer hospitalization days (P < 0.05), and not as many received systemic antibiotic therapy (P < 0.0001). We conclude that G-CSF accelerates neutrophil recovery in chemotherapy-induced neutropenia in childhood malignancies.

References

Jan 1, 1990·International Journal of Cell Cloning·C InoueH Saito
Jun 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W L FurmanV M Santana
Jun 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N V Cheung, G Heller
Apr 1, 1990·Ergonomics·H Kanis, M F Weegels
Jan 1, 1989·European Journal of Haematology·E Platzer
Aug 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V T DeVita
May 1, 1970·The Proceedings of the Nutrition Society·S W Cox

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Citations

Feb 14, 2002·British Journal of Haematology·Thomas Lehrnbecher, Karl Welte
Apr 16, 2002·Current Opinion in Hematology·John E Levine, Laurence A Boxer
Mar 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Miflin, S E Kinsey
Nov 1, 1995·European Journal of Clinical Investigation·S MakinodaS Fujimoto
Mar 1, 1994·Pediatric Hematology and Oncology·Y L Danon
Apr 1, 2009·Expert Review of Hematology·Thomas Lehrnbecher, Ursula Creutzig
Sep 1, 1996·Pediatric Hematology and Oncology·M Kalmanti
Oct 13, 2021·Pediatric Blood & Cancer·Hannah JeterEmily Waite

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