PMID: 6411668Jul 1, 1983Paper

Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
J M HinsonJ R Snapper

Abstract

To examine the role of circulating granulocytes in the airway changes caused by endotoxemia, we measured the response of chronically instrumented unanesthetized sheep to endotoxemia before and after granulocyte depletion with hydroxyurea. Granulocyte depletion did not affect the increases in mean pulmonary arterial pressure caused by endotoxin [peak pressure 59 +/- 8 cmH2O +/- (SE) control, 51 +/- 8 cmH2O granulocyte depleted]. However, the early (30-60 min after endotoxin) airway response to endotoxemia was markedly attenuated. Without granulocyte depletion, endotoxin caused dynamic compliance (Cdyn) to decrease to 41 +/- 10% of the base-line value and total lung resistance (RL) to increase to 283 +/- 61% of base line. When animals were granulocyte depleted, endotoxin decreased Cdyn to 69 +/- 6% (P less than 0.05) of base line and increased RL to 141 +/- 20% of base line (P less than 0.05). Granulocyte depletion also attenuated the effect of endotoxin on arterial oxygenation. During the maximum airway response to endotoxin, the alveolar-to-arterial oxygen gradient was 47 +/- 5 Torr in control studies and 32 +/- 2 Torr in granulocyte depleted studies (P less than 0.05). We conclude that interaction of granulocytes with the lung...Continue Reading

Citations

Mar 1, 1992·The American Review of Respiratory Disease·A P WheelerG R Bernard
Mar 1, 1991·The American Review of Respiratory Disease·J F SimpsonB Meyrick
Jan 1, 1988·The American Review of Respiratory Disease·R BurrellD E Hinton
Jan 1, 1993·The British Journal of Surgery·A C WindsorH J Sugerman
Jun 1, 1993·The American Review of Respiratory Disease·J R GossageJ R Snapper
Jun 1, 1992·The American Review of Respiratory Disease·C ShindohG Supinski
Jun 18, 1999·The Journal of Trauma·O TasakiB A Pruitt
Sep 1, 1989·The American Review of Respiratory Disease·P E Wright, G R Bernard
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Dec 1, 1989·The American Journal of the Medical Sciences·A R Dal Nogare
Aug 1, 1993·The American Journal of the Medical Sciences·A C WindsorA A Fowler

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