Effect of granulocyte-macrophage colony-stimulating factor on the number of leucocytes and course of Listeria monocytogenes infection in naive and leucocytopenic mice

Immunology
A M BuismanR van Furth

Abstract

This study concerns the effect of recombinant murine granulocyte-macrophage colony-stimulating factor (GM-CSF) on the number of circulating leucocytes, activation of peritoneal macrophages and proliferation of Listeria monocytogenes in various organs of naive and leucocytopenic mice. Mice were rendered leucocytopenic by sublethal total body irradiation or cyclophosphamide treatment. GM-CSF treatment enhanced the number of granulocytes and monocytes in peripheral blood during L. monocytogenes infection in naive mice, but not in irradiated or cyclophosphamide-treated mice. In naive mice, irradiated and cyclophosphamide-treated mice, GM-CSF did not affect the course of L. monocytogenes infection in thigh muscle, spleen and liver. However, GM-CSF treatment significantly increased the number of macrophages in the peritoneal cavity of naive mice during infection; these macrophages were more enlarged and showed a higher frequency of binucleated and multinucleated cells relative to non-GM-CSF-treated mice. Together, these results demonstrated that GM-CSF increased the number of circulating granulocytes and monocytes, and the number of peritoneal macrophages during infection with L. monocytogenes in naive mice, but did not affect the co...Continue Reading

References

Nov 23, 1989·The New England Journal of Medicine·J E GroopmanD T Scadden
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·E StanleyA R Dunn
Mar 21, 1996·The New England Journal of Medicine·F S Southwick, D L Purich
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L H WexlerM E Horowitz
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

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Citations

Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert T WheelerGerald R Fink
Oct 16, 2010·Annals of the New York Academy of Sciences·Erin F NichollsRobert E W Hancock
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahboob H QureshiBeth A Garvy

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