Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge.

Allergy
Guy W ScaddingStephen R Durham

Abstract

Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects of treatments. To use grass pollen nasal allergen challenge (NAC) to investigate the effects of allergen immunotherapy in a cross-sectional study. We studied nasal and cutaneous responses in untreated subjects with seasonal grass-pollen allergic rhinitis (n = 14) compared with immunotherapy-treated allergics (n = 14), plus a nonatopic control group (n = 14). Volunteers underwent a standardized NAC with 2000 biological units of timothy grass allergen (equivalent to 1.3 μg major allergen, Phl p5). Nasal fluid was collected and analysed by ImmunoCAP and multiplex assays. Clinical response was assessed by symptom scores and peak nasal inspiratory flow (PNIF). Cutaneous response was measured by intradermal allergen injection. Retrospective seasonal symptom questionnaires were also completed. Immunotherapy-treated patients had lower symptom scores (P = 0.04) and higher PNIF (P = 0.02) after challenge than untreated allergics. They had reduced early (P = 0.0007) and late (P < 0.0001) skin responses, and lower retrospective seasonal symptom scores (P < 0.0001). Compared to untreated allergics, immunotherapy-treated patients h...Continue Reading

References

Aug 1, 1989·The Journal of Allergy and Clinical Immunology·P S CreticosP S Norman
Sep 1, 1988·The Journal of Allergy and Clinical Immunology·M Castells, L B Schwartz
Aug 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·B LeynaertJ Bousquet
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·N TeradaA Konno
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Torres LimaS Durham
Nov 2, 2004·The European Respiratory Journal·V Bauchau, S R Durham
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Anil NandaHarold S Nelson
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Kayhan T Nouri-AriaStephen R Durham
Jan 6, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E M ErinT T Hansel
Apr 10, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Martin J BurtonRichard M Rosenfeld
Sep 22, 2007·Allergy and Asthma Proceedings·Christine KlemensMatthias F Kramer
Apr 1, 2008·The Journal of Allergy and Clinical Immunology·James N FrancisStephen J Till
Mar 23, 2010·The Journal of Allergy and Clinical Immunology·Bo L K ChawesTrevor T Hansel
Feb 10, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eli O Meltzer, Don A Bukstein
Apr 27, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Huss-MarpH Behrendt
Jul 5, 2012·Journal of Immunological Methods·Guy W ScaddingPeter Adler Wurtzen
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Robert L JacobsSunil K Ahuja

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Citations

Mar 8, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sadan SoyyigitBetul Ayse Sin
Mar 15, 2016·Immunotherapy·Peter A WürtzenPeter S Andersen
Dec 27, 2015·Allergy·Ulrich M ZisslerCarsten B Schmidt-Weber
Jul 20, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A O Eifan, S R Durham
Nov 8, 2016·The Journal of Allergy and Clinical Immunology·Robert K Bush
Sep 30, 2016·Therapeutic Advances in Respiratory Disease·Jasper H KappenMohamed H Shamji
Dec 21, 2016·The Journal of Allergy and Clinical Immunology·Alessandro Sette, Véronique Schulten
Jul 25, 2018·Expert Review of Clinical Immunology·Amelia LicariGiorgio Ciprandi
Dec 5, 2014·Journal of Leukocyte Biology·Taylor A Doherty
Nov 15, 2017·Current Opinion in Allergy and Clinical Immunology·Sveva CastelliPaolo M Matricardi
Sep 11, 2018·Current Opinion in Allergy and Clinical Immunology·Mark W TennAnne K Ellis
Dec 4, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
Feb 2, 2019·Frontiers in Immunology·Julia Eckl-DornaRudolf Valenta
Mar 12, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Wenping WangYifan Guo
Sep 22, 2017·Clinical and Translational Allergy·Georg BoelkeTorsten Zuberbier
Mar 19, 2020·Bioscience Reports·Hiu Yan LamKwang Seok Ahn
Jan 24, 2020·Current Opinion in Allergy and Clinical Immunology·Giovanni PassalacquaDiego G Peroni
Jul 12, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O PfaarL Klimek
Jan 7, 2021·Cancers·Monika Zajkowska, Barbara Mroczko
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji
Mar 2, 2021·Frontiers in Immunology·Beatriz León, Andre Ballesteros-Tato
Sep 10, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Umut C KucuksezerCezmi A Akdis
Mar 31, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Mohamed H ShamjiStephen R Durham
May 18, 2021·Allergy·Mohamed H ShamjiR J Joost van Neerven

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Methods Mentioned

BETA
lavage
Assay

Software Mentioned

GraphPad
GraphPad Prism

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