Effect of green tea catechins on the pharmacokinetics of digoxin in humans

Drug Design, Development and Therapy
Tae-Eun KimJongmin Lee

Abstract

Previous in vitro studies have reported the inhibitory effect of green tea on p-glycoprotein (p-gp) encoded by ABCB1. This study aimed to investigate the effect of green tea on the pharmacokinetics of digoxin, a typical probe drug of p-gp. Sixteen healthy volunteers participated in this study. At Day 1, 0.5 mg of digoxin was administered via oral route. After a 14-day washout period, 630 mg of green tea catechins (GTC) was administered via oral route, followed by 0.5 mg of digoxin 1 hour later. From Day 16 through Day 28, 630 mg of GTC was administered alone. At Day 29, 630 mg of GTC and 0.5 mg of digoxin were administered in the same way as Day 15. Blood samples for the pharmacokinetic assessments of digoxin were collected up to 8 hours after each dose. Pharmacokinetic parameters were estimated by noncompartmental analysis. Area under the curve (AUC) and peak plasma concentration (Cmax) were compared using mixed effect model between digoxin alone and digoxin with GTC. ABCB1 was genotyped to determine whether its polymorphism affects digoxin-GTC interaction. Fifteen subjects completed the study. Compared to digoxin alone, the concomitant administration of digoxin and GTC significantly reduced the systemic exposure of digoxin: g...Continue Reading

Citations

Nov 28, 2019·Expert Opinion on Drug Metabolism & Toxicology·Rolf Teschke, Tran Dang Xuan
Jan 31, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Khaled S AbdelkawyNoha M El-Khodary
Feb 25, 2020·Cardiovascular Therapeutics·Irina-Iuliana CostacheAna Clara Aprotosoaie
Aug 18, 2020·Breast Cancer Research and Treatment·C Louwrens BraalRon H J Mathijssen

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SAS

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