Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database

The Journal of Clinical Endocrinology and Metabolism
E O ReiterM B Ranke

Abstract

Treatment with GH has been used to correct the growth deficit in children with GH deficiency (GHD). Although successful in increasing height velocity, such treatment often falls short of helping patients achieve full genetic height potential. This study set out to analyze near-final height (FH) data from a cohort of GH-treated children with idiopathic GHD. Of 1258 evaluable patients in the Pfizer International Growth Database (KIGS) with GHD, 980 were of Caucasian origin, and 278 were of Japanese origin; 747 had isolated GHD (IGHD), and 511 had multiple pituitary hormone deficiencies (MPHD). Near-FH, relation to midparental height, and factors predictive of growth outcomes were the main outcome measures. Median height sd scores (SDS) at the start of treatment were -2.4 (IGHD) and -2.9 (MPHD) for Caucasian males and -2.6 (IGHD) and -3.4 (MPHD) for females, respectively; comparable starting heights were -2.9 (IGHD) and -3.6 (MPHD) for Japanese males and -3.3 (IGHD) and -4.0 (MPHD) for females, respectively. Corresponding near-adult height SDS after GH treatment were -0.8 (IGHD) and -0.7 (MPHD) for Caucasian males and -1.0 (IGHD) and -1.1 (MPHD) for females, respectively; and -1.6 (IGHD) and -1.9 (MPHD) for Japanese males and -2.1...Continue Reading

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Citations

Sep 22, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Maria A KalinaEwa Małecka-Tendera
Feb 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John D MahanD Aaron Davis
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Jan 15, 2014·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Yoko Oyakawa BarcelliRaquel Barrio Castellanos
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Nov 1, 2011·Indian Journal of Pediatrics·Raphaël Rappaport
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Jul 9, 2011·Advances in Pediatrics·Bradley S Miller
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Sep 29, 2011·Clinical Endocrinology·Ian P HughesUNKNOWN Australasian Paediatric Endocrine Group (APEG)
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Aug 17, 2006·The Journal of Clinical Endocrinology and Metabolism·Stefano ZucchiniAlessandro Cicognani
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Dec 21, 2018·Archives of Disease in Childhood·Sheila ShepherdLeena Patel
Jul 29, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jane LoftusPaul Dimitri
Nov 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Bradley S MillerKevin C J Yuen

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