PMID: 11932561Apr 5, 2002Paper

Effect of growth hormone on exercise tolerance in children with cystic fibrosis

Medicine and Science in Sports and Exercise
Matthias HütlerRalph Beneke

Abstract

The effect of growth hormone (GH) treatment on exercise tolerance in children with cystic fibrosis was investigated. 10 prepubertal children (mean +/- SD; age: 12.1 +/- 1.7 yr; height: 137.4 +/- 9.2 cm; body mass: 27.8 +/- 4.2 kg; forced expiratory volume in 1 s (FEV1): 68 +/- 22% predicted) were randomly assigned to either control period (CON, standard therapy) or recombinant human growth hormone (GH) period (additional GH treatment, 0.11-0.14 IU.kg-1, daily, s.c.) for the first 6 months, and then assigned to the other period for the next 6 months. At study entry and after each period, anthropometric data, pulmonary function, and exercise capacity (peak exercise capacity, .VO(2peak), and isokinetic muscle strength) were measured. Changes in height (+4.3 +/- 1.0 cm), total body mass (+2.2 +/- 0.8 kg), and lean body mass (LBM, +2.9 +/- 0.7 kg) were significantly higher (P < 0.01) after GH treatment compared with CON. Pulmonary function did not significantly change in either of the periods. In contrast to CON, GH treatment improved absolute .VO(2peak) (+19%, P < 0.01), peak ventilation (+14%, P < 0.01), and peak oxygen pulse (+18%, P < 0.01). Analysis of variance revealed that most of the changes (71%) in .VO(2peak) could be expl...Continue Reading

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Citations

Jul 27, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Dana S HardinKenneth J Ellis
Jul 27, 2004·The Journal of Burn Care & Rehabilitation·Oscar E SumanDavid N Herndon
Feb 18, 2004·Journal of Endocrinological Investigation·M BidlingmaierC J Strasburger

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