Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men

Clinical Pharmacology and Therapeutics
Gesche JürgensHanne Rolighed Christensen

Abstract

Our objective was to study the effect of recombinant human growth hormone (rhGH) on hepatic cytochrome P450 (CYP) activity in 30 healthy elderly men. The study was carried out as a randomized, double-blind, placebo-controlled parallel-group study. rhGH or placebo was administered for a period of 12 weeks. CYP activity was measured before, after 12 weeks of rhGH and placebo administration, and at 4 weeks after termination of rhGH and placebo administration with use of the biomarker reactions of CYP1A2 (caffeine), CYP2C19 (mephenytoin), CYP2D6 (sparteine), CYP3A4 (endogenous cortisol metabolism), and antipyrine clearance as common markers of CYP activity. The metabolic ratio of caffeine increased significantly in the group that received growth hormone compared with placebo (median difference, 4.55; 95% confidence interval (CI), 1.64 to 8.60; versus -0.90; 95% CI, -5.70 to 1.36), indicating an induction of CYP1A2. Moreover, the S/R ratio of mephenytoin showed a small but significant increase (median difference, 0.02; 95% CI, 0 to 0.31; versus 0; 95% CI, -0.01 to 0.06), indicating an inhibition of CYP2C19. There were no significant changes of the metabolic ratios of cortisol and sparteine or the antipyrine clearance compared with p...Continue Reading

Citations

Apr 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Susanne LöfgrenMagnus Ingelman-Sundberg
Jun 2, 2009·Molecular Pharmacology·David J Waxman, Minita G Holloway
Jun 26, 2004·Breast Cancer Research : BCR·Chi-Chen HongNorman F Boyd
Apr 7, 2010·Expert Opinion on Drug Metabolism & Toxicology·Hyunyoung Jeong
Apr 9, 2004·Journal of Intensive Care Medicine·Eric S Nylen, Beat Muller
Oct 16, 2008·British Journal of Cancer·N A HelsbyM Findlay
Jul 15, 2006·European Journal of Clinical Pharmacology·Giovanni TarantinoVincenzo Basile
Oct 12, 2007·Basic & Clinical Pharmacology & Toxicology·Blanca SinuésAngel Ferrandez-Longás
Feb 8, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tsutomu SakumaNobuo Nemoto
Mar 15, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tadahiro HashitaNobuo Nemoto
Nov 18, 2005·The Journal of Pharmacology and Experimental Therapeutics·Connie CheungFrank J Gonzalez
Feb 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni GuaraldiUNKNOWN SHIVER Network
Aug 16, 2003·British Journal of Clinical Pharmacology·Joel O OlubodunDavid J Greenblatt
Jan 22, 2004·Biochemical and Biophysical Research Communications·Tsutomu SakumaNobuo Nemoto
Sep 24, 2004·Biochemical and Biophysical Research Communications·Tsutomu SakumaNobuo Nemoto

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