PMID: 9539301Apr 16, 1998Paper

Effect of growth hormone therapy in children with achondroplasia: growth pattern, hypothalamic-pituitary function, and genotype

European Journal of Endocrinology
H TanakaYoshiki Seino

Abstract

Although there are a few reports on GH therapy in achondroplasia, these were based on a small sample and/or short-term observation. To clarify the effectiveness of GH treatment on short stature in achondroplasia and hypochondroplasia, a long-term treatment study in a larger number of patients was performed. Forty-two children (16 males and 26 females, age 3-14 years) with achondroplasia were examined in this study. Initially, we evaluated hypothalamic-pituitary function and point mutation analysis as previously reported. After the evaluation, the children were treated with GH for more than 2 years; then post-treatment growth velocity and body proportion parameters were determined. The 35 typical variants of our achondroplasia patients showed previously reported point mutation in the fibroblast growth factor receptor 3 gene. The annual height gain during GH therapy was significantly greater than that before therapy (3.9 +/- 1.0 cm/year before treatment vs 6.5 +/- 1.8 cm/year for the first year and 4.6 +/- 1.6 cm/year for the second year of treatment). The body disproportion had not been aggravated during the treatment period. We conclude that GH might be beneficial in the treatment of short stature in children with achondroplasi...Continue Reading

Citations

Dec 11, 2008·Journal of Bone and Mineral Metabolism·Daisuke HaradaYoshiki Seino
Oct 6, 1999·Pediatric Research·U RamaswamiC G Brook
Aug 25, 1999·Lancet·T OnoY Seino
Jul 3, 2015·Experimental and Therapeutic Medicine·Jingfang LiuYan Wang
Feb 10, 2004·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Nobuhiko Haga
Oct 24, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Pascal RichetteChantal Stheneur
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshitaka YamanakaYoshiki Seino
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mio KoikeYoshiki Seino
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joan C MariniC Michael Reing
Dec 31, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Masaki MatsushitaNaoki Ishiguro
May 18, 2013·Surgical Neurology International·Serge Y Rasskazoff, Konstantin V Slavin
Jun 27, 2006·The Journal of Bone and Joint Surgery. British Volume·B WesthoffU Schneider
Feb 23, 2020·International Journal of Molecular Sciences·Riko NishimuraLerdluck Ruengsinpinya
Feb 28, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·C Kanaka-Gantenbein
Feb 8, 2020·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Takuo KubotaKeiichi Ozono
May 16, 2017·European Journal of Pediatrics·Daisuke HaradaYoshiki Seino
Dec 25, 2009·American Journal of Medical Genetics. Part a·María Luisa Martínez-FríasUNKNOWN ECEMC Working Group

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