Effect of guided bone regeneration on bone quality surrounding dental implants

Journal of Biomechanics
Trenton B JohnsonDo-Gyoon Kim

Abstract

Bone quality as well as its quantity at the implant interface is responsible for determining stability of the implant system. The objective of this study is to examine the nanoindentation based elastic modulus (E) at different bone regions adjacent to titanium dental implants with guided bone regeneration (GBR) treated with DBM and BMP-2 during different post-implantation periods. Six adult male beagle dogs were used to create circumferential defects with buccal bone removal at each implantation site of mandibles. The implant systems were randomly assigned to only GBR (control), GBR with demineralized bone matrix (DBM), and GBR with DBM + recombinant human bone morphogenetic protein-2 (rhBMP-2) (BMP) groups. Three animals were sacrificed at each 4 and 8 weeks of post-implantation healing periods. Following buccolingual dissection, the E values were assessed at the defects (Defect), interfacial bone tissue adjacent to the implant (Interface), and pre-existing bone tissue away from the implant (Pre-existing). The E values of BMP group had significantly higher than control and DBM groups for interface and defect regions at 4 weeks of post-implantation period and for the defect region at 8 weeks (p < 0.043). DBM group had higher E ...Continue Reading

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Citations

Sep 11, 2020·Journal of Biomechanical Engineering·Manon FraulobGuillaume Haïat
Sep 17, 2020·Acta Biomaterialia·Sophie Le CannGuillaume Haïat
Sep 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Nayara Koba de MouraEliandra de Sousa Trichês
Sep 27, 2020·Medical Engineering & Physics·Manon FraulobGuillaume Haïat

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