Effect of Gusuibu graft on bone formation

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Ricky W K Wong, A Bakr M Rabie

Abstract

We compared the amount of new bone produced by Gusuibu in collagen grafts to that produced by bone grafts and collagen grafts. Twenty bone defects were created in the parietal bone of 14 New Zealand White rabbits. In the experimental group, 5 defects were grafted with Gusuibu extract mixed with absorbable collagen sponge, and 5 defects were grafted with autogenous endochondral bone. In the control groups, 5 defects were grafted with absorbable collagen sponge alone (active control) and 5 were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histologic assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 150 sections using image analysis. A total of 24% and 90% more new bone were present in defects grafted with Gusuibu in collagen grafts than those grafted with bone and collagen, respectively. No bone was formed in the passive control group. Gusuibu in collagen grafts have the effect of increased new bone formation locally and can be used as a bone graft material.

References

Aug 1, 1996·International Journal of Oral and Maxillofacial Surgery·A B Rabie, R K Lie Ken Jie
Feb 13, 1999·Journal of Chemical Information and Computer Sciences·X YanZ Xu
May 18, 1999·European Journal of Orthodontics·R W Wong, A B Rabie
Apr 11, 2000·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·A B Rabie, S H Chay
Sep 30, 2000·The British Journal of Oral & Maxillofacial Surgery·A B RabieU Hägg

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Citations

Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Solon T Kao, Daniel D Scott
Sep 12, 2012·Journal of Biomedical Materials Research. Part a·Kuo-Yu ChenChun-Hsu Yao
Mar 3, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ricky W K Wong, A Bakr M Rabie
Dec 3, 2009·Phytotherapy Research : PTR·R W K Wong, A B M Rabie
May 13, 2010·The Open Biomedical Engineering Journal·R W K Wong, A B M Rabie
Jul 6, 2017·BMC Complementary and Alternative Medicine·Vicente F Pinheiro NetoAntonio C R Borges
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rusin ZhaoJithendra Ratnayake
Nov 5, 2020·Current Drug Targets·Hitesh ChopraInderbir Singh

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