Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury

Japanese Journal of Pharmacology
T MuraseY Sameshima

Abstract

The effects of H2-antagonists on acetaminophen-induced hepatic injury were examined. Rats were administered acetaminophen at the dose of 800 mg/kg body, 60 hr after injection of 3-methylcholanthrene. As an H2-antagonist, cimetidine (200 mg/kg), ranitidine (50 mg or 100 mg/kg), or famotidine (20 mg or 40 mg/kg) was administered before and after acetaminophen injection. The group administered only acetaminophen had been severely damaged as evaluated by changes in serum transaminase, P-450 content, aminopyrine demethylation, glutathione content and histological study, but administration of 200 mg cimetidine together with acetaminophen significantly reduced the hepatic injury to nearly the control level. Ranitidine had no protective effect against hepatic injury at the dose of 50 mg, which appears to have the same antacid effect as 200 mg cimetidine, whereas it had a slight but significant protective effect as evaluated by the transaminase level, glutathione content and histological study at the dose of 100 mg. Famotidine had no effect against acetaminophen induced hepatic injury. Because famotidine had no effect, the protection by H2-antagonist against acetaminophen-induced hepatic injury cannot be explained by the decrease in hep...Continue Reading

References

Sep 22, 1979·Lancet·D HetzelJ Miners
Sep 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S RendićH H Ruf
Feb 1, 1985·Japanese Journal of Pharmacology·T MuraseY Sameshima
May 1, 1982·British Medical Journal·A M HeagertyL Patel
May 14, 1983·British Medical Journal·H SpahnH D Janisch
Jun 15, 1984·Biochemical Pharmacology·J O MinersD J Birkett
May 1, 1980·The New England Journal of Medicine·U Klotz, I Reimann
May 1, 1982·Annals of Internal Medicine·J FeelyA J Wood
Mar 19, 1981·The New England Journal of Medicine·J FeelyA J Wood
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL

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Citations

Jun 26, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min HeRenbin Huang
Mar 1, 1995·Human & Experimental Toxicology·K K BurkhartB H Rumack
May 23, 2002·Journal of the American Animal Hospital Association·Kevin P WallaceScott Smith
Aug 9, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael E MullinsWilliam E Freeman
May 1, 1990·Japanese Journal of Pharmacology·S Nakanishi, H Okuno

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