Effect of haloperidol and d-amphetamine on cerebral tyramine and octopamine levels

European Journal of Pharmacology
A V Juorio, T J Danielson


The administration of d-amphetamine or haloperidol produced a marked reduction in the rat striatum concentration of p-tyramine, an effect that was not observed in the mesolimbic system. However, the administration of d-amphetamine to haloperidol-pretreated animals produced in both brain areas a marked reduction in p-tyramine levels. Furthermore, this latter treatment produced a marked increase in the m-tyramine levels in both brain regions. Hypothalamic p-octopamine levels were reduced by d-amphetamine, but not by haloperidol or haloperidol in the presence of d-amphetamine.


Jan 1, 1985·Progress in Neurobiology·J C David, J F Coulon
Mar 23, 2004·Neuropharmacology·Raffaella GeracitanoNicola B Mercuri
Mar 15, 2005·The Journal of Pharmacology and Experimental Therapeutics·Gregory M MillerBertha K Madras

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