Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs

Journal of Anesthesia
E MasakiK Kobayashi

Abstract

We investigated the relative effects of 0.5, 1.0, 1.5, 2.0 MAC halothane and enflurane, and concurrent noxious stimulus on hepatic blood flow and oxygen consumption in 14 mongrel dogs randomly divided into groups of seven each. Hepatic arterial and portal venous blood flow (HABF and PVBF, respectively) were measured continuously using ultrasonic transit time flow meter. Mean arterial blood pressure (MAP), cardiac index (CI), hepatic oxygen supply, and hepatic oxygen consumption (HVO2) were measured. Halothane significantly deceased HABF, but not PVBF in a dose dependent manner. Enflurane did not affect HABF and PVBF significantly. MAP and CI decreased in both groups, with halothane producing more marked decreases than enflurane. HVO2 did not change with enflurane, but did with halothane, producing significant differences, with halothane being greater at 1.5, 2.0 MAC. A noxious stimulus only caused minor change in blood flow. The results suggest that liver blood flow and oxygen consumption are affected differently by halothane and enflurane and that halothane has a stronger tendency to cause an imbalance between liver oxygen supply and consumption than dose enflurane.

References

Jul 1, 1979·British Journal of Anaesthesia·G W Black
Jan 1, 1975·Acta Anaesthesiologica Scandinavica·L ThulinL Irestedt
Oct 1, 1985·Anesthesiology·J G Stock, L Strunin
Apr 1, 1969·The American Journal of Physiology·M L Katz, E N Bergman
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·M Andreen
Oct 1, 1982·Anesthesia and Analgesia·L R Pohl, J R Gillette
Jan 1, 1963·Anesthesiology·G L BRODY, R B SWEET

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