Feb 1, 1976

Effect of halothane anesthesia on muscle, liver, thyroid, and adrenal-function tests in man

Clinical Chemistry
R E JohnstoneR C Ebersole


Seven healthy men volunteers received 6.6 +/- 1.3 (SD) percent-hours of halothane oxygen anesthesia without surgery. Serum bilirubin, alanine aminotransferase, and aspartate aminotransferase significantly increased after anesthesia, which may indicate subclinical liver-cell damage. Creatine kinase of skeletal muscle origin increased above 90 U/liter in six subjects, indicating subclinical muscle-cell damage. Cortisol, triiodothyronine uptake, thyroxine, and free thyroxine index increased significantly immediately after anesthesia. Serum bromide concentrations had increased by fivefold on the second day after anesthesia, and on the ninth day was still elevated fourfold. Oral temperatures increased 0.7 degrees C 6 h post-anesthesia, possibly because of increased thyroxine activity. Lactate dehydrogenase, hydroxybutyrate dehydrogenase and gamma-glutamyltransferase activities did not change significantly. No drugs administered during the course of this study chemically interfered with any of the test methods used.

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Mentioned in this Paper

Alcohol Oxidoreductases
Cell Injury
Macro-Creatine Kinase
Gamma-glutamyl transferase
Thyroxine Measurement
Bilirubin, (4E,15E)-Isomer
Serum Bilirubin Measurement
Gamma Glutamyl Transferase Measurement

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