Effect of halothane on phenylephrine-induced vascular smooth muscle contractions in endotoxin-exposed rat aortic rings

Critical Care Medicine
T E GrissomS M Muldoon

Abstract

a) To determine the response of endotoxin-exposed vascular smooth muscle to exogenous vasoconstrictors during concomitant exposure to an inhaled anesthetic (halothane); and b) to determine if excess nitric oxide production is responsible for any altered response. In vitro, prospective, repeated-measures, dose-response study. University/medical school experimental physiology laboratory. Adult male Sprague-Dawley rats, whose aortae were studied in an in vitro preparation. Thoracic aortae were excised from anesthetized animals and cut into 3-mm rings. After incubation in aerated organ baths containing a modified essential medium with or without Escherichia coli lipopolysaccharide (100 micrograms/mL) at 37 degrees C for 5 hrs, the rings were removed and suspended in separate baths for isometric tension recording. Phenylephrine dose-response data (10(-10) to 10(-5) M) were determined for lipopolysaccharide- and nonlipopolysaccharide-treated rings. After washout and equilibration, two vessels (one each lipopolysaccharide- and nonlipopolysaccharide-treated) were additionally exposed to 2% halothane and phenylephrine dose-response determinations were repeated for all vessels. This procedure was repeated for 1% halothane in a separate e...Continue Reading

References

Dec 1, 1990·British Journal of Pharmacology·I R HutchesonN K Boughton-Smith
Jun 1, 1990·Anesthesia and Analgesia·P Van der LindenJ L Vincent
Nov 15, 1990·Biochemical and Biophysical Research Communications·R G KilbournR F Lodato
Nov 13, 1987·Biochemical and Biophysical Research Communications·M W RadomskiS Moncada
Jan 1, 1988·Anesthesiology·S M MuldoonW Freas
Aug 1, 1987·Acta Anaesthesiologica Scandinavica·C F SchaeferM F Wilson
Jun 1, 1985·Annals of Surgery·W E WalkerJ H Duke
Oct 25, 1984·The New England Journal of Medicine·R L NicholsJ Mills

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Citations

Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HellerD Lebrec
May 27, 2008·Journal of Anesthesia·Noboru TodaYoshio Hatano
Jun 23, 2012·Journal of the Chinese Medical Association : JCMA·Cheng-Ming TsaoChin-Chen Wu
Mar 1, 2000·The Journal of Laboratory and Clinical Medicine·H W Kim, A G Greenburg

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