PMID: 8594035Nov 1, 1995Paper

Effect of [Hb] on blood flow distribution and O2 transport in maximally working skeletal muscle

Journal of Applied Physiology
S S KurdakM C Hogan

Abstract

We investigated whether the reduction in calculated muscle diffusion capacity for O2 (DmO2) previously shown to occur with lowered hemoglobin concentration ([Hb]) perfusion of maximally working muscle is related to changes in the blood flow distribution. If blood flow distribution is altered during low [Hb] conditions, the reduction in the calculated DmO2 may in fact be due to increasing heterogeneity and not to some other hemoglobin-related factor. Color-stained (15-microns-diam) microspheres were injected into the artery supplying maximally working isolated in situ dog gastrocnemius muscle (n = 6) while it was being perfused (flow controlled by pump perfusion) with whole blood at three different levels of [Hb] (14.1 +/- 0.5, 8.9 +/- 0.4, and 5.7 +/- 0.4 (SE) g/100 ml] in a blocked-order design. Muscle blood flow and arterial PO2 were not changed as [Hb] was altered. Maximal O2 uptake (11.8 +/- 1.3, 8.2 +/- 0.8, and 6.0 +/- 0.9 ml.100 g-1 min-1 for those [Hb] values, respectively) and the associated estimate of DmO2 (0.25 +/- 0.03, 0.18 +/- 0.03, and 0.15 +/- 0.03 ml.100 g-1.min-1.Torr-1) declined significantly (P < 0.05) with [Hb]. However, the dispersion of the blood flow distribution did not change significantly and, if any...Continue Reading

Citations

Jul 20, 1999·Journal of Applied Physiology·S DeemE R Swenson
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Otto EichelbrönnerIan H Chin-Yee
Nov 15, 1997·The American Journal of Physiology·M D KoskolouB Saltin
Apr 12, 2000·Acta Physiologica Scandinavica·P D Wagner
Sep 18, 1997·Journal of Applied Physiology·K R Turley, J H Wilmore

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