Effect of HCV infection on glucose metabolism in pregnant women with HIV receiving HAART

HIV Clinical Trials
Carmela PinnettiEnrica Tamburrini

Abstract

A prospective study was designed to evaluate the prevalence and determinants of glucose metabolism abnormalities (GMAs) among HIV-1-infected pregnant women receiving highly active antiretroviral therapy (HAART). Blood samples were collected in fasting conditions and following a 100 g oral glucose tolerance test among HIV-infected pregnant women consecutively followed at asingle HIV reference centre in 2001-2008. GMAs were defined by glucose intolerance(IGT) or gestational diabetes (GDM), according to the National Diabetes Data Group criteria. Predictors of GMAs were assessed in univariate and multivariate analyses. Overall, 78 women with no history of diabetes or GMAs were eligible for analysis. All were on stable HAART with either nevirapine or protease inhibitors (PIs) from at least 4 weeks at the time of sampling. GMAs during pregnancy were observed in 20 women (25.6%; GDM: 6, 7.7%; IGT: 14, 17.9%). In a multivariate analysis, after adjusting for age and ongoing antiretroviral treatment (PI or nevirapine), GMAs in pregnancy were significantly associated with HCV coinfection(adjusted odds ratio 4.16; 95% CI, 1.22-14.1;p = .022). No maternal or neonatalcomplications were observed. GMAs represent a relevant issue in the managem...Continue Reading

References

Feb 12, 1998·Annals of Internal Medicine·F VisnegarwalaD M Musher
Feb 12, 1998·Annals of Internal Medicine·J A Eastone, C F Decker
Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T LaskusJ Rakela
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Aug 14, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I BalikH Yasa
Sep 7, 1999·Hospital Medicine·A J Levine, T R Graham
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CaroniaG J Alexander
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M P Dubé
Dec 15, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A B MorrisD Y Allen
Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C HadiganS Grinspoon
Sep 18, 2001·Current Infectious Disease Reports·Mark S. Sulkowski
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
May 1, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ellen R CooperUNKNOWN Women and Infants' Transmission Study Group
Nov 20, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Morris SchambelanUNKNOWN International AIDS Society-USA
Mar 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica E JustmanKathryn Anastos
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shruti H MehtaMark S Sulkowski
Feb 26, 2004·American Journal of Obstetrics and Gynecology·D Heather WattsUNKNOWN PACTG 316 Study Team
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adeel A ButtAmy C Justice
Dec 17, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cecilia YoonMarshall J Glesby
Mar 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ruth E TuomalaUNKNOWN Women and Infants Transmission Study
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea A HowardEllie E Schoenbaum
Jul 16, 2005·Diabetes/metabolism Research and Reviews·Patrícia El BeituneFrancisco Mauad Filho
Dec 8, 2005·JAMA : the Journal of the American Medical Association·Risto J Kaaja, Ian A Greer
Jan 27, 2006·Journal of Viral Hepatitis·A LonardoG Ruggiero
Mar 4, 2006·Epidemiology and Infection·M FloridiaUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
Apr 21, 2006·AIDS Research and Human Retroviruses·Teresa García-BenayasVincent Soriano
May 2, 2006·Obstetrics and Gynecology·Jennifer H TangGeorge D Wendel
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruno LedergerberUNKNOWN Swiss HIV Cohort Study
Feb 13, 2008·Diabetes Care·Stephane De WitUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
May 20, 2008·American Journal of Obstetrics and Gynecology·Steven A PergamStephen E Hawes
Nov 6, 2008·HIV Medicine·M I González-ToméUNKNOWN Spanish Cohort of HIV-infected Mother-Infant Pairs
Feb 3, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Phyllis C TienJessica E Justman
Feb 19, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine Samaras

❮ Previous
Next ❯

Citations

Feb 24, 2016·Molecular and Cellular Endocrinology·Stella Liong, Martha Lappas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

HIV Medicine
M I González-ToméSpanish Cohort of HIV-infected Mother-Infant Pairs
American Journal of Obstetrics and Gynecology
Jane HittiAIDS Clinical Trials Group 5084 Study Team
The New England Journal of Medicine
Charles S ChaselaBAN Study Group
© 2021 Meta ULC. All rights reserved