PMID: 9545619Apr 18, 1998Paper

Effect of head-upright tilt on the dynamic of cerebral autoregulation

Clinical Physiology
G LefthériotisJ L Saumet

Abstract

The effect of head-upright tilting on the rate of cerebral autoregulation was studied in 12 healthy volunteers (nine men and three women; age range 20-36 years). The dynamics of cerebral autoregulation was determined from the rate of change in cerebral resistance (RoR) during a drop in arterial blood pressure induced by rapid deflation of a 3-min ischaemic thigh cuff and from the ratio of changes in cerebral blood flow and arterial blood pressure (CAI) during the recovery period after the drop in arterial blood pressure. The test was performed supine and with 40 degrees head-up tilt (40 degrees HUT). Middle cerebral artery mean blood flow velocity was measured by transcranial Doppler simultaneously with peripheral arterial blood pressure using Finapres. The thigh cuff deflation induced a larger drop in arterial pressure during 40 degrees HUT [median -28% (25 percentile -36, 75 percentile -19)] than in the supine position [-16% (-23, -15)] (P < 0.01) and in cerebral resistance [supine: -12% (-15, -6); 40 degrees HUT: -15% (-20, -12); P < 0.05]. There was no significant change in RoR [15% s-1 (12, 15)] and CAI [1.9 (1.5, 3.1)] measured supine and during 40 degrees HUT [RoR: 13% s-1 (12, 15); CAI: 1.3 (0.99, 1.9)]. During the drop...Continue Reading

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Citations

Feb 14, 2009·European Journal of Applied Physiology·James HearnDavid George Behm
Apr 17, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ronney B Panerai
Dec 29, 2013·BioMed Research International·David K KungDavid M Hasan
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Jun 21, 2014·Journal of the American Heart Association·Maw Pin TanSteve W Parry
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Feb 9, 2018·Physiological Reports·Man Y LamRonney B Panerai
Nov 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M SerradorA W Gelb

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