Effect of Helicobacter pylori eradication on the outcome of reflux esophagitis and chronic gastritis in the elderly. A randomized, multicenter, eight-month study

Gerontology
Alberto PilottoAging and Acid-Related Disease Study Group

Abstract

The effect of Helicobacter pylori eradication on the clinical outcome of esophagitis in elderly patients is controversial. To evaluate the effect of H. pylori eradication on clinical outcome of esophagitis and on chronic gastritis and its activity. Sixty-one symptomatic elderly patients with esophagitis and H. pylori infection were randomized into two groups. Group 1 (PPI-only, 30 patients) was treated with pantoprazole 40 mg daily for 2 months followed by pantoprazole 20 mg daily for a further 6 months; group 2 (PPI + eradication, 31 patients) was treated as group 1 plus a 1-week course of amoxicillin 1 g twice daily and clarithromycin 250 mg twice daily. Endoscopy with gastric biopsies, 13C-UBT and clinical visits were repeated after 2 and 8 months. After 8 months, the intention-to-treat H. pylori eradication rates were 19.2% in group 1 vs. 80.7% in group 2 (p < 0.0001). No differences between group 1 and group 2 were observed in symptoms improvement (77 vs. 77%, p = n.s.) and healing rates of esophagitis (92.3 vs. 88.5%, p = n.s.). A significant decrease in the prevalence of moderate/severe chronic gastritis (from 52.2 to 4.7%, p = 0.002) and its activity (from 38 to 4.7%, p = 0.02) was observed in the antrum of patients of ...Continue Reading

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Citations

Jun 20, 2007·Journal of Clinical Gastroenterology·Diklar MakolaSheila E Crowe
Jan 13, 2010·World Journal of Gastroenterology : WJG·Kum Hei RyuHyun Joo Song
Aug 24, 2006·Helicobacter·Tamara Matysiak-BudnikStanislas Chaussade
Jan 11, 2017·The American Journal of Gastroenterology·William D CheySteven F Moss
Oct 5, 2007·Expert Review of Anti-infective Therapy·Nathalie Salles, Francis Mégraud
Jul 6, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Shivaram Prasad SinghVikram Kate
Jul 27, 2021·Panminerva Medica·Marilena DurazzoRinaldo Pellicano

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