PMID: 11339417May 8, 2001Paper

Effect of Helicobacter pylori eradication on gastric mucosal phospholipid content and its fatty acid composition

Journal of Gastroenterology and Hepatology
T OriharaA Watanabe

Abstract

Whether Helicobacter pylori eradication alters gastric mucosal phospholipid contents and their fatty acid composition remains unclear. The aim of the present study was to clarify the effect of H. pylori eradication on gastric mucosal phosphatidylcholine (PC) content and its fatty acid composition. Endoscopic biopsy specimens were taken from the antrum and body of each of 19 asymtomatic male volunteers for detection of H. pylori, histopathological assessment of gastritis, phospholipid determination and fatty acid analysis. All the subjects with H. pylori infection were treated with eradication therapy. Endoscopy and tissue sampling were repeated again 1 and 6 months after all treatment. In eight subjects, H. pylori infection was evident and was successfully eradicated. Pretreatment degrees of lymphocytes and plasma cells (inflammation) and polymorphonuclear neutrophils (activity) were greater in H. pylori-positive subjects compared with H. pylori-negative subjects (P<0.001), whereas the degree of inflammation decreased (P<0.001), and neutrophils had completely disappeared at 6 months after eradication. Moreover, the gastric mucosal PC contents at the antrum and body were unchanged within 1 month after cessation of treatment, but...Continue Reading

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Citations

Oct 23, 2002·Alimentary Pharmacology & Therapeutics·M HojoN Sato
Oct 22, 2009·FEMS Microbiology Letters·Hirofumi ShimomuraYoshikazu Hirai
Sep 1, 2005·The American Journal of Gastroenterology·Peter MalfertheinerUNKNOWN Lejondal H. pylori-Gastric Cancer Task Force

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