Effect of Helicobacter pylori eradication on gastric carcinogenesis

Laboratory Investigation; a Journal of Technical Methods and Pathology
Judith Romero-GalloRichard M Peek

Abstract

Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet the effects of bacterial eradication on carcinogenesis remain unclear. Animal models provide important insights into factors that are involved in gastric carcinogenesis, and we previously utilized such a model to demonstrate that an in vivo-adapted H. pylori strain, 7.13, rapidly and reproducibly induces inflammation-mediated gastric carcinoma. In the current study, we used this bacterial strain as a prototype to define the role of targeted antimicrobial therapy in gastric carcinogenesis. Mongolian gerbils were infected with H. pylori for 4 or 8 weeks, treated with antimicrobial agents or vehicle, and then euthanized at 8 weeks after the completion of therapy. All infected gerbils developed gastritis; however, inflammation was significantly attenuated in animals receiving antimicrobial therapy. Gastric dysplasia or cancer developed in >60% of the gerbils that remained persistently colonized with H. pylori, but in none of the animals treated with antibiotics following 4 weeks of infection. Infection with H. pylori for 8 weeks prior to therapy resulted in an attenuation, but not complete prevention, of pre-malignant...Continue Reading

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Citations

Jun 27, 2008·The Journal of Biological Chemistry·Daniel P O'BrienRichard M Peek
Oct 12, 2010·Clinical Microbiology Reviews·Lydia E WroblewskiKeith T Wilson
Oct 12, 2010·Clinical Microbiology Reviews·Alicia H Chang, Julie Parsonnet
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May 18, 2016·The Journal of Infectious Diseases·Uma KrishnaRichard M Peek
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Sep 17, 2013·Journal of Surgical Oncology·Guanghua LiYulong He
Feb 7, 2015·PLoS Pathogens·Nina Bertaux-SkeirikYana Zavros
Nov 28, 2008·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Hyun Ja KimDong Soo Han
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Aug 10, 2010·Cancer Letters·Sung Soo KimSteven F Moss

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