Effect of Helicobacter pylori lipopolysaccharide (LPS) and LPS derivatives on the production of tissue factor and plasminogen activator inhibitor type 2 by human blood mononuclear cells

The Journal of Infectious Diseases
N SemeraroA P Moran

Abstract

Different Helicobacter pylori lipopolysaccharides (LPSs) and LPS-derivatives were studied for their ability to induce the production of procoagulant activity (PCA) and plasminogen activator inhibitor type 2 (PAI-2) by human blood mononuclear leukocytes. Smooth (S)- and rough (R)-form LPSs caused a similar increase in cell-associated PCA (tissue factor) and PAI-2 antigen release. Both effects were potentiated by fetal bovine serum via a CD14-mediated mechanism. The potency of H. pylori LPSs was approximately 1000-fold lower than that of Salmonella typhimurium LPSs. When H. pylori LPS derivatives (dephosphorylated R-LPS, S-lipid A, and R-lipid A) were used, PCA and PAI-2 production were markedly reduced. R-lipid A was approximately 4-fold less efficient than S-lipid A. These findings suggest that the induction of monocyte tissue factor and PAI-2 by H. pylori LPS is influenced by the lipid A structure and modulated by the core oligosaccharide and that phosphate groups present in both regions may play an important role.

Citations

Apr 15, 2016·FEMS Microbiology Reviews·Rita F MaldonadoMiguel A Valvano
Jul 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mehdi Sharifi-RadJavad Sharifi-Rad
Dec 10, 1999·Immunopharmacology and Immunotoxicology·A Di LeoE Jirillo
Aug 12, 2014·World Journal of Gastroenterology : WJG·Magdalena ChmielaKarolina Rudnicka
May 1, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Asif SukriNik Ritza Kosai

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