PMID: 6166710May 1, 1981Paper

Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus

The Journal of Experimental Medicine
K N Leung, G L Ada

Abstract

Injection of mice with infectious or noninfectious preparations of influenza virus induces the formation of T cells which, when added to primary tissue cultures of normal spleen cells exposed to influenza virus, enhance the generation of effector T cells which mediate delayed-type hypersensitivity (DTH) reaction. The enhancing cells possess Thy-1 and Ly-1 surface antigens are radioresistant and antigen-specific. If infectious virus was used to stimulate the DTH response in vitro, help was delivered whether homologous or heterologous A strain influenza virus was used to generate the helper T cells (Th) in vivo. In contrast, only Th cells generated using homologous virus were effective if noninfectious virus was used to stimulate the DTH response in vitro. Peak helper activity occurred 2 d after virus injection and the Th cells were only effective if added to the primary cultures within 24 h after addition of the stimulating antigen. The Th cells enhanced the generation of both classes of DTH effector cells, i.e., those that are Ly-1 positive and IA-subregion restricted and those that are Ly-2,3 positive and K,D-region restricted. The activity of the Th cells was found to be IA-subregion restricted and this was shown to operate a...Continue Reading

References

Apr 1, 1979·European Journal of Immunology·P A Bretscher
Nov 1, 1979·The Journal of Experimental Medicine·H von Boehmer, W Haas
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Nov 1, 1979·The Journal of Experimental Medicine·R B Ashman, A Müllbacher
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Apr 1, 1978·The Journal of Experimental Medicine·T J Braciale, K L Yap
Dec 1, 1978·The Journal of Experimental Medicine·L L Baum, L M Pilarski
Apr 1, 1980·The Journal of Experimental Medicine·U H KoszinowskiH D Klenk
Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber
May 1, 1980·The Journal of Experimental Medicine·R B CorleyM A Cooley
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J AnderssonF Melchers
Oct 1, 1980·The Australian Journal of Experimental Biology and Medical Science·K N Leung, G L Ada
Jan 1, 1980·Scandinavian Journal of Immunology·K N Leung, G L Ada

❮ Previous
Next ❯

Citations

Oct 11, 2005·Autoimmunity Reviews·Maurizio Zanetti
Mar 1, 1982·Immunobiology·M H SchreierM J van Zwieten
Jun 1, 1986·The Journal of Experimental Medicine·Y MoriM Wakashin
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·P A Bretscher
Apr 3, 2008·Journal of Immunotoxicology·Gary R Burleson, Florence G Burleson
May 23, 2015·Scandinavian Journal of Immunology·P A Bretscher
Mar 3, 2019·Scandinavian Journal of Immunology·Peter A Bretscher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.