Effect of Hemidesmus indicus on ischemia-reperfusion injury in the isolated rat heart

Pharmaceutical Biology
Vinoth Kumar Megraj KhandelwalT Ravingerová

Abstract

The root extract of Hemidesmus indicus (Linn.) R. Br. (Asclepiadaceae) (HI) was studied for its cardioprotective effect in Langendorff-perfused rat hearts. HI was perfused for 15 min at a concentration of 0.09 g/L prior to 30 min global ischemia/120 min reperfusion (I/R). Recovery of functional parameters, reperfusion arrhythmias, and infarct size (TTC staining) served as the end-points. After 15 min of perfusion with HI, the left ventricular developed pressure (LVdevP) and HR (heart rate) were not altered significantly (p>0.05), as compared with the pre-drug values. During R, HI showed a significantly higher (p<0.05) recovery of LVdevP at nearly all time points. The recovery of maximal rate of pressure development (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) at 40 min of R were significantly better than in non-treated controls. There was also a significant reduction in the total number of ventricular premature beats (VPB) and duration of ventricular tachycardia (VT). HI can protect ischemic myocardium against contractile dysfunction and reperfusion-induced arrhythmias and reduce the extent of irreversible tissue damage following I/R in rat hearts.

References

Feb 1, 1995·The Journal of Pharmacy and Pharmacology·C Y HongF L Hsu
Mar 10, 2001·The Journal of Nutrition·H Matsuura
Nov 21, 2001·Cardiovascular Drugs and Therapy·O SzárszoiF Kolár
Mar 22, 2003·Journal of Ethnopharmacology·A Anoop, M Jegadeesan
Jul 16, 2003·Journal of Ethnopharmacology·N K MaryJ Padikkala
Jul 23, 2003·Molecular and Cellular Biochemistry·Peter KaplanDusan Dobrota
Jul 13, 2004·Resuscitation·Brian S PalmerMark G Angelos
Jan 24, 2006·Journal of Molecular and Cellular Cardiology·Meijing WangDaniel R Meldrum
Dec 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Zhanna MakazanNaranjan S Dhalla
Jul 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·S Suchalatha, C S Shyamala Devi

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Citations

Aug 14, 2012·Phytotherapy Research : PTR·Sarita Das, Satpal Singh Bisht
Apr 1, 2018·Cardiovascular Therapeutics·Lovedeep SinghAmteshwar S Jaggi

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