Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue

The Journal of Sexual Medicine
M Talaat Abdel AzizRafal Olszanecki

Abstract

Cyclic guanosine monophosphate (cGMP) levels can be regulated by heme oxygenase-1 and 2 (HO-1 and HO-2)-derived carbon monoxide (CO). Assessment of the effect of upregulating CO in rat corpora cavernosa (CC) on cavernous cGMP. Three experimental groups were studied: first group (N = 40), short-term HO induction over 2 weeks by injection of intraperitoneal increasing doses of hemin; the second group (N = 40) was subjected to intracavernosal injection of CO donor, CORM-3, or its inactive form (iCORM-3) over 2 weeks; the third group (N = 60) was subdivided into three subgroups: the first one received a combined hemin and CORM-3, the second one received hemin and its inhibitor stannus mesoporphyrin (SnMP), and third one received a combined hemin, CORM-3, and SnMP. In CC, HO-1 and HO-2 gene expression, Northern blot and Western blot, cGMP levels, and HO enzyme activity. In the first group, maximum induction of HO-1 gene expression, HO enzyme activity, and cGMP occurred with 4-mg hemin dose with a successive increase over 2 weeks. In the second group, CORM-3 increased cGMP by twofold compared with iCORM-3, and also increased HO-1 protein. In the third group, SnMP inhibited the enhancing effect of CORM-3 and HO on erectile signaling m...Continue Reading

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Citations

Dec 3, 2013·Pharmacology, Biochemistry, and Behavior·K DecaluwéJ Van de Voorde
Jan 17, 2016·The Journal of Pharmacy and Pharmacology·Bart PauwelsJohan Van de Voorde
Jan 28, 2009·The Journal of Sexual Medicine·Mohamed T Abdel AzizDina Sabry
Oct 7, 2009·The Journal of Sexual Medicine·Mohamed Talaat Abdel AzizAhmed Demery
Jun 30, 2011·The Journal of Sexual Medicine·Mohamed Talaat Abdel AzizAhmed Abdel Aziz
Jul 5, 2012·The Journal of Sexual Medicine·Kelly DecaluwéJohan Van de Voorde
Jan 23, 2008·The Journal of Sexual Medicine·M Talaat Abdel AzizAhmed T Abdel Aziz
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May 7, 2011·Journal of Experimental & Clinical Cancer Research : CR·Mohamed T Abdel azizFatma M Taha
Oct 7, 2018·International Journal of Impotence Research·Taymour MostafaMaroa S Omar

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