Abstract
Bacterial meningitis and septicemia are invasive bacterial diseases, representing a significant cause of morbidity and mortality worldwide. Both conditions are characterized by an impressive inflammatory response, resulting rapidly in cerebral edema, infarction, hydrocephalus, and septic shock with multiple organ failure. Despite advances in critical care, outcome and prognosis remain critical. Available adjunctive treatments to control the inflammatory response have shown encouraging results in the evolution of patients with sepsis and systemic inflammation, but meningococcal or pneumococcal infection has not been investigated. We herein report five patients with similar critical pathological conditions, characterized by pneumococcal or meningococcal sepsis and treated with hemoadsorption for cytokine removal. All patients showed a progressive stabilization in hemodynamics along with a rapid and marked reduction of catecholamine dosages, a stabilization in metabolic disorders, and less-than-expected loss of extremities. Therapy proved to be safe and well tolerated. From this first experience, extracorporeal cytokine removal seems to be a valid and safe therapy in the management of meningococcal and pneumococcal diseases and ma...Continue Reading
References
Apr 12, 2003·Brain : a Journal of Neurology·Stefan Kastenbauer, Hans-Walter Pfister
Jun 24, 2003·Archives of Disease in Childhood·N PathanM Levin
Aug 9, 2003·Intensive Care Medicine·Juan M Flores-CorderoFrancisco Murillo-Cabezas
Oct 29, 2004·The New England Journal of Medicine·Diederik van de BeekMarinus Vermeulen
Jan 6, 2006·The New England Journal of Medicine·Diederik van de BeekEelco F M Wijdicks
Mar 14, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Martine HoogmanBen Schmand
Apr 25, 2008·Critical Care Medicine·Zhi-Yong PengJohn A Kellum
Jul 9, 2010·Clinical Microbiology Reviews·Matthijs C BrouwerDiederik van de Beek
Nov 13, 2012·Lancet·Diederik van de BeekAllan R Tunkel
Oct 1, 2013·Expert Review of Anti-infective Therapy·Roland NauHelmut Eiffert
Dec 20, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R MuralidharanA A Rabinstein
Dec 4, 2014·Journal of Neuroimmunology·Tatiana BarichelloJoão Quevedo
Sep 10, 2015·The International Journal of Artificial Organs·Burkhard HinzRolf Kaiser
Apr 1, 2016·Anesthesiology·Jecko Thachil
May 4, 2016·The International Journal of Artificial Organs·Karl TrägerHelmut Reinelt
Mar 28, 2017·Critical Care : the Official Journal of the Critical Care Forum·Klaus KogelmannMatthias Drüner
May 20, 2017·The International Journal of Artificial Organs·Karl TrägerHelmut Reinelt
Jun 8, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sigrun FrieseckeAxel Nierhaus