Effect of hemodialysis on contact group of coagulation factors, platelets, and leukocytes

The American Journal of Medicine
N D VaziriE Hung

Abstract

Earlier reports have suggested possible activation and consumption of factor XII during hemodialysis. To investigate this possibility, a series of in vivo and in vitro experiments were conducted using different dialysis membranes and two different dialysates (acetate and bicarbonate). Factors XII and XI activities, factor XII concentration, and high-molecular-weight kininogen were measured. In addition, platelet count, white blood cell count, and hematocrit were monitored. Contrary to the previous reports, no discernible consumption of factor XII, factor XI, or high-molecular-weight kininogen was found irrespective of the type of membrane or the composition of the dialysate used. Transient leukopenia was noted with cellulosic membranes, whereas none occurred with polyacrylonitrile dialyzers. The composition of dialysate did not affect the white blood cell count during dialysis.

References

Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Dec 1, 1972·Journal of Clinical Pathology·E N Wardle, D A Piercy
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka

Citations

Jan 1, 1992·International Urology and Nephrology·M Kuźniewski, W Sułowicz
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N D VaziriS Said
Oct 1, 1985·Journal of the Royal Society of Medicine·A Bush, R Gabriel

Related Concepts

Orlon
Acrylic Resins
Blood Protein Electrophoresis
Alphacel
Factor XI
Factor XII
Hemodialysis
Immunoelectrophoresis
Kininogen
Differential White Blood Cell Count Procedure

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.