PMID: 18709999Aug 20, 2008Paper

Effect of heparin on the activated partial thromboplastin time in parturients receiving combined spinal and epidural anesthesia for caesarean section

Masui. The Japanese journal of anesthesiology
Yumiko KohnoN Seo

Abstract

Although administration of heparin is a useful method for preventing deep venous thromboembolism, one limitation is the increased risk of bleeding. In this retrospective investigation, we evaluated the effect of heparin on the activated partial thromboplastin time (APTT) in parturients who received caesarean section under combined spinal and epidural anesthesia. In order to prevent deep venous thromboembolism, heparin 5000 units twice daily, was subcutaneously given in 199 parturients who received caesarean section under combined spinal and epidural anesthesia. Measured APTT was compared between before and after administration of the heparin. The heparin extended APTT from 29.6 +/- 2.5 sec to 35.4 +/- 5.9 sec (P < 0.05). An extended APTT by 1.5 times or more was found in 1.1% of the patients. There was no deep thromboembolism nor increased bleeding, including intra-abdominal and epidural hematoma. Subcutaneously administered heparin, 5000 units twice daily, might have a role in preventing deep venous thromboembolism in parturients undergoing caesarean section. Strict vigilance, however, should be provided against increased bleeding associated with epidural hematoma in parturients with an indwelling epidural catheter.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.