PMID: 9176726Jan 1, 1997Paper

Effect of hepatic nerve stimulation and norepinephrine on the laser Doppler flux signal from the surface of the perfused rat liver

International Journal of Microcirculation, Clinical and Experimental
A M Wheatley, N E Almond

Abstract

The effect of hepatic nerve stimulation and norepinephrine (NE) on the laser Doppler signal from the surface of the perfused rat liver was tested. The livers from male Wistar rats were perfused in situ via the portal vein with Krebs-Henseleit buffer containing 20% bovine erythrocytes (37 degrees C, pH 7.4) and total liver blood flow (TLBF) was by timed collection of effluent. Portal vascular resistance (PVR) was calculated from the pressure difference across the liver. Linearity of laser Doppler flowmetry (LDF) with TLBF was confirmed in all preparations. Stimulation of the hepatic nerves (2 ms, 20 V) was performed at frequencies between 0.5 and 20 Hz (n = 11). NE was added to the buffer at concentrations between 10(-10) and 10(-6) M (n = 8). A stimulus-dependent rise in PVR occurred during hepatic nerve stimulation (basal, 3.11 +/- 0.26 dyn s cm-5) and NE administration (basal, 2.62 +/- 0.29 dyn s cm-5), with a maximum effect at 20 Hz (311 +/- 45%) and 10(-6) M (591 +/- 72%), respectively. Both LDF and TLBF fell during nerve stimulation and NE. A linear relationship (r = 0.99; p < 0.001) between change in TLBF (%) and LDF flux (%) was found for NE (10(-10) to 10(-6) M). During nerve stimulation, the fall in TLBF and LDF flux w...Continue Reading

Citations

Aug 13, 2002·Autonomic Neuroscience : Basic & Clinical·Mieko KurosawaMasashi Yoneda
Nov 1, 2005·The Journal of Surgical Research·Attila SzijártóPéter Károly Kupcsulik
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Robert S McCuskey
Sep 28, 2002·Transplantation·Michael N TawadrousAntony M Wheatley

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