Abstract
Hepatocellular carcinoma (HCC) is a complication of chronic hepatitis B and C virus (HBV and HCV) infection. New York City (NYC) has a high prevalence of HBV and HCV, and infected persons likely face increased mortality from HCC and other causes. We describe the mortality profile of NYC residents with HBV or HCV, emphasizing the contributions of HCC and HIV coinfection. Two existing data sets were combined to examine all individuals diagnosed with HBV or HCV in NYC first reported to the Health Department during 2001-2012 and their HCC, HIV, and vital status. Logistic regression was used to calculate the odds of HCC diagnosis by viral hepatitis status, whereas Cox proportional hazard regression was used to estimate the hazard of death by HCC/HIV status. In total, 120 952 and 127 933 individuals were diagnosed with HBV or HCV, respectively. HCV-infected individuals had 17% higher odds of HCC diagnosis than HBV-infected individuals and 3.2 times higher odds of HIV coinfection. Those with HCV were twice as likely to die during the study period (adjusted hazard ratio, 2.04; 95% confidence interval, 1.96-2.12). The risk of death increased for those with HIV or HCC and was highest for those with both conditions. HCC and HIV represent ...Continue Reading
References
Mar 31, 2006·Archivos de la Sociedad Española de Oftalmología·J Bruix
Mar 28, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix
Oct 29, 2009·Gastroenterology·Gary L DavisLinda W Jennings
Jan 12, 2011·Current HIV/AIDS Reports·Eva A Operskalski, Andrea Kovacs
Jan 17, 2012·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Anne Marie FranceSharon Balter
Apr 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oluwaseun Falade-NwuliaChloe L Thio
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
May 10, 2013·Epidemiology and Infection·S BalterK Konty
Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen N LyScott D Holmberg
Oct 12, 2013·Addiction·Daniel FusterJudith I Tsui
Nov 2, 2013·Public Health Reports·Kate DreznerSharon Balter
Jan 5, 2014·Public Health Reports·Melissa A SanchezSandra Huang
Feb 14, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessie PinchoffJennifer Fuld
Apr 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Helen M ChunUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
May 29, 2014·International Journal of Molecular Sciences·Claudio M MastroianniVincenzo Vullo
Jul 6, 2014·PloS One·Baligh R YehiaVincent Lo Re
Jul 22, 2014·Lancet·Colette J SmithJens D Lundgren
Aug 30, 2014·Epidemiology and Infection·C PrussingJ Fuld
Jan 16, 2015·Preventing Chronic Disease·Paulina OngAnn Madsen
Jul 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian R EdlinTracy Swan
Aug 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Henry RobertsScott D Holmberg
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen N LyScott D Holmberg
Sep 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Miranda S MooreFabienne Laraque
Aug 2, 2017·BMC Infectious Diseases·Hugo PerazzoValdiléa G Veloso
Sep 15, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel Ajwad ButtAbdul-Badi Abou-Samra
May 21, 2018·Infectious Disease Clinics of North America·Anne C MoormanUNKNOWN CHeCS Investigators
Citations
Oct 28, 2019·Addiction·Bruce R Schackman, Zachary F Meisel
Sep 1, 2018·BMC Research Notes·Birendra Prasad GuptaSantosh Chaudhary
Jul 20, 2019·Molecular Medicine Reports·Zuohong MaWenxin Li
Feb 2, 2022·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Chao YangGuiju Sun