Abstract
As obesity is becoming an epidemic, diet programs, including low-calorie diets, are continuously being developed. It is generally believed that a low-calorie diet is commonly followed by a resting metabolic rate decrease and ultimate weight regain. Ephedra sinica and evodia rutaecarpa are known to have sympathomimetic and anti-obesity effects. This study was a prospective; double-blinded, randomized and placebo-controlled clinical trial to evaluate the effects of ephedra sinica and evodia rutaecarpa on resting metabolic rate (RMR), body composition and short-term safety in obese Korean premenopausal women on a low-calorie diet. One hundred and twenty-five otherwise healthy obese women (body mass index > or =25 kg/m(2)) were recruited and randomly assigned to three groups: ephedra group (n = 41), evodia group (n = 45) and placebo group (n = 39). Subjects were administered ephedra extract in capsules (pseudo-ephedrine 31.52 mg) or evodia extract in capsules (evodiamine 6.75 mg, rutaecarpine 0.66 mg) or placebo capsules as well as participating in a low-calorie diet for 8 weeks. Resting metabolic rate and body composition were measured at baseline, 4 and 8 weeks. Basic serum tests were performed to evaluate the short-term safety a...Continue Reading
References
Jul 1, 1992·Metabolism: Clinical and Experimental·A AstrupF Quaade
Jun 1, 1986·Journal of Pharmaceutical Sciences·N ShojiY Ohizumi
Feb 1, 1993·The American Journal of Clinical Nutrition·S AlgerE Ravussin
Dec 1, 1996·Endocrinology and Metabolism Clinics of North America·J J Zachwieja
Feb 1, 1997·Journal of Clinical Pharmacology·L M WhiteM Estes
Apr 17, 1998·Obesity Research·H M SeagleJ O Hill
Nov 20, 1998·JAMA : the Journal of the American Medical Association·S B HeymsfieldC Nunez
Jun 5, 1999·The American Journal of Clinical Nutrition·A AstrupB Buemann
Jun 1, 2000·Obesity Research·J HirschL J Aronne
Sep 14, 2000·Planta medica·Y KobayashiT Kamiya
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerJ L Solomon
Oct 3, 2001·Planta medica·Y KobayashiT Kamiya
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerT Meredith
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F L Greenway
Mar 18, 2003·Annals of Internal Medicine·Stephen BentMichael G Shlipak
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Paul G ShekelleJames Gagné
May 3, 2003·Journal of the American Dietetic Association·David C NiemanMelanie D Austin
Apr 22, 2004·Journal of Ethnopharmacology·Eunjung KoHyunsu Bae
Aug 5, 2004·Obesity Research·Frank L GreenwaySteven R Smith
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·Matthew D VukovichNeal L Benowitz
Citations
Feb 22, 2014·Journal of Ethnopharmacology·Bong-Soo KimHojun Kim
Apr 16, 2016·Journal of Acupuncture and Meridian Studies·Min-Ho NamByung-Cheol Lee
Jan 5, 2014·Journal of Ethnopharmacology·Duyeol KimJong-Koo Kang
Jan 5, 2013·Journal of Ethnopharmacology·Ellie J Y KimGeorge Q Li
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Nancy Dewi YulianaRobert Verpoorte
Jul 9, 2011·Natural Product Reports·Ilze VermaakJosias H Hamman
Nov 26, 2019·Medicine·Dae-Hyun JoJae-Dong Lee
Jan 28, 2020·Diabetes, Obesity & Metabolism·Alison MaunderNicholas R Fuller
Jun 2, 2018·Journal of Analytical Methods in Chemistry·Ji Hyun JeongSeong Ho Ham
Jul 25, 2018·Scientific Reports·Limei WangAtanas G Atanasov
Dec 4, 2019·Phytotherapy Research : PTR·Moloud PayabBagher Larijani
Jan 8, 2020·Toxins·Wonnam KimMyung Sook Oh
Aug 19, 2020·Journal of Ethnopharmacology·Wei ZhangXiaoqiu Liu
Jan 8, 2021·Chemistry & Biodiversity·Karol JędrejkoBożena Muszyńska
Jun 24, 2021·Obesity·John A BatsisSrividya Kidambi
Jul 5, 2021·Environmental Science and Pollution Research International·Mohamed SeifZaizhao Wang