Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women

Journal of Acupuncture and Meridian Studies
Ho-Jun KimByeong-Pyo Ko

Abstract

As obesity is becoming an epidemic, diet programs, including low-calorie diets, are continuously being developed. It is generally believed that a low-calorie diet is commonly followed by a resting metabolic rate decrease and ultimate weight regain. Ephedra sinica and evodia rutaecarpa are known to have sympathomimetic and anti-obesity effects. This study was a prospective; double-blinded, randomized and placebo-controlled clinical trial to evaluate the effects of ephedra sinica and evodia rutaecarpa on resting metabolic rate (RMR), body composition and short-term safety in obese Korean premenopausal women on a low-calorie diet. One hundred and twenty-five otherwise healthy obese women (body mass index > or =25 kg/m(2)) were recruited and randomly assigned to three groups: ephedra group (n = 41), evodia group (n = 45) and placebo group (n = 39). Subjects were administered ephedra extract in capsules (pseudo-ephedrine 31.52 mg) or evodia extract in capsules (evodiamine 6.75 mg, rutaecarpine 0.66 mg) or placebo capsules as well as participating in a low-calorie diet for 8 weeks. Resting metabolic rate and body composition were measured at baseline, 4 and 8 weeks. Basic serum tests were performed to evaluate the short-term safety a...Continue Reading

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Citations

Apr 16, 2016·Journal of Acupuncture and Meridian Studies·Min-Ho NamByung-Cheol Lee
Jan 5, 2014·Journal of Ethnopharmacology·Duyeol KimJong-Koo Kang
Jan 5, 2013·Journal of Ethnopharmacology·Ellie J Y KimGeorge Q Li
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Nancy Dewi YulianaRobert Verpoorte
Jul 9, 2011·Natural Product Reports·Ilze VermaakJosias H Hamman
Jun 2, 2018·Journal of Analytical Methods in Chemistry·Ji Hyun JeongSeong Ho Ham
Jan 8, 2021·Chemistry & Biodiversity·Karol JędrejkoBożena Muszyńska
Jul 5, 2021·Environmental Science and Pollution Research International·Mohamed SeifZaizhao Wang

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