Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats

Molecular Medicine Reports
Yosuke NakazawaHiroomi Tamura

Abstract

Cataracts are a major cause of blindness worldwide. As anti‑cataract pharmaceutical therapies require long‑term treatment, identifying anti‑cataract compounds that are ubiquitous in the human diet, have no adverse effects and are affordable, is of paramount importance. The present study focused on hesperetin and its derived compounds, hesperetin stearic acid ester (Hes‑S) and hesperetin oleic acid ester (Hes‑O), in order to investigate their therapeutic potential to treat cataracts in a selenite animal model. Thirteen‑day‑old Sprague Dawley rats were divided into 12 groups. Animals in groups 1 and 7 were subcutaneously injected with vehicle, those in groups 2 and 8 were administered hesperetin, those in groups 3 and 9 received stearic acid, those in groups 4 and 10 were injected with oleic acid, those in groups 5 and 11 were administered Hes‑S, and those in groups 6 and 12 received Hes‑O (10 nmol/kg body weight on days 0, 1 and 2). Animals in groups 7 to 12 were treated with sodium selenite (20 µmol/kg body weight given 4 h following the test compound treatment on day 0) to induce cataract. On day 6, rats had less severe central opacities and lower stage cataracts than rats in the selenite treatment‑only control groups. The lev...Continue Reading

References

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Nov 17, 2015·Investigative Ophthalmology & Visual Science·Moncef KhairallahUNKNOWN Vision Loss Expert Group of the Global Burden of Disease Study
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Mar 30, 2017·Open Medicine·Yosuke NakazawaMakoto Takehana
Aug 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yosuke NakazawaHiroomi Tamura

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Citations

Jan 23, 2020·Pharmaceuticals·Segewkal H HeruyeCatherine A Opere

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