Effect of hexachlorocyclohexane isomers on calmodulin mRNA expression in the central nervous system

Brain Research. Molecular Brain Research
S BarrónJ Serratosa

Abstract

Three different calmodulin genes that encode the same protein have been found in the brain of all mammalian species so far examined. Little is known about the factors involved in regulating the expression of this gene family in the central nervous system. We have investigated the possibility of differential expression of two calmodulin genes, CaM I and CaM II, which are expressed strongly in neuronal cells in the adult rat brain, after treatment with the gamma (lindane) and the delta isomers of the hexachlorocyclohexane (HCH). In this study a decrease of CaM I mRNA (mainly in the 4.0 kb transcript) was found in the cortex of the rats after 24 h of isomer administration. CaM I expression seemed to be more sensitive to delta isomer action, whereas the gamma isomer acted mainly at CaM II level. The levels of mRNA of calmodulin CaM II gene were also found to decrease after lindane administration; delta-HCH produced an increase of this transcript. These results were obtained by Northern blot analysis and confirmed by means of in situ hybridization. Our results suggest that levels of neuronal calmodulin mRNA species are modified in response to changes in neuronal activity.

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Citations

May 30, 2001·Brain Research·C CasalJ Serratosa
Sep 25, 2002·Life Sciences·Arpad PalfiKaroly Gulya
Sep 3, 2002·Neuroscience·E KortvelyK Gulya
Dec 29, 1999·Reproductive Toxicology·L SilvestroniS Palleschi
May 2, 2001·The International Journal of Biochemistry & Cell Biology·C SolàJ Serratosa
Sep 19, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A PalfiK Gulya
Apr 28, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A PalfiK Gulya

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