Effect of high-dose sodium selenite in cardiac surgery patients: A randomized controlled bi-center trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Tanja SchmidtChristoph Haberthür

Abstract

Cardiac surgery is accompanied by oxidative stress and systemic inflammatory response, which may be associated with organ dysfunction and increased mortality. Selenium and selenoenzymes are important constituents of anti-oxidative defense. We hypothesized that high-dose sodium selenite supplementation can attenuate the postoperative inflammation and might, therefore, improve clinical outcome. Randomized, placebo-controlled, double-blinded, bi-center study on 411 adult patients undergoing elective cardiac surgery. Patients received an intravenous bolus of 4000 μg selenium (in the form of sodium selenite) or placebo after induction of anesthesia and 1000 μg/d selenium or placebo during their intensive care unit (ICU) stay. Primary outcome measure was the Sequential Organ Failure Assessment (SOFA) score on the second postoperative day. Secondary endpoints included the change in perioperative selenium levels, change of inflammatory and cardiac markers, use of vasoactive medication, incidence of acute kidney injury, ICU and hospital length of stay, and mortality. The perioperative administration of high-dose sodium selenite prevented the postoperative drop of blood and serum selenium levels, reduced the number of patients depending ...Continue Reading

Citations

Oct 13, 2017·Intensive Care Medicine·Pierre SingerMette M Berger
Jun 7, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sebastian WendtChristian Stoppe
Dec 18, 2019·Intensive Care Medicine Experimental·Mathun KuganesanAlex Dyson
Dec 18, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Mette M Berger, William Manzanares
Dec 17, 2021·Acta chirurgica Belgica·Eric E VinckDiana Cárdenas

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