Effect of high-dose steroids on anastomotic complications after proctocolectomy with ileal pouch-anal anastomosis

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Jeffrey P LakeR W Beart

Abstract

This review was designed to determine whether "high-dose" steroid therapy (> or =20 mg prednisone/day) increases the likelihood of anastomotic complications after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). The hospital records of 100 patients undergoing proctocolectomy with IPAA were reviewed. Patient characteristics were analyzed to determine what factors were associated with higher rates of anastomosis-related complications. Seventy-one of our patients were given diverting ileostomies, whereas the remaining 29 underwent a single-stage procedure. Fifty-four percent of the patients in our review were taking steroids preoperatively, 39 of whom were on high-dose therapy. The overall anastomosis-related complication rate was 14%. There was no significant difference in complication rates with respect to age, steroid use, steroid dose, use of a diverting ileostomy, type of anastomosis, duration of disease, or presence of backwash ileitis. A trend toward higher leakage rates was found in patients undergoing single-stage procedures (10.3% vs. 2.8%, P=0.14) as well as in patients undergoing single-stage procedures on high-dose steroids (22% vs. 5.0, P=0.22). Nevertheless, neither of these trends was found to ...Continue Reading

Citations

Sep 4, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andreas D RinkKarl-Heinz Vestweber
Feb 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Léon Maggiori, Yves Panis
May 9, 2012·World Journal of Gastroenterology : WJG·Alberto BiondiAlessandro Fichera
Sep 27, 2015·BMJ Open·Eva Bjerre OstenfeldUNKNOWN Danish Colorectal Cancer Group
Oct 16, 2012·Cirugía española·Monica Millán ScheidingSebastiano Biondo
Oct 22, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Thévy HorYann Parc
May 31, 2013·Alimentary Pharmacology & Therapeutics·S J MehtaJ O Lindsay
Nov 13, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T F EriksenI Gögenur
Mar 1, 2008·Journal of Crohn's & Colitis·S P L TravisUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Sep 16, 2014·Inflammatory Bowel Diseases·Bikash Devaraj, Andreas M Kaiser
Sep 18, 2010·Inflammatory Bowel Diseases·Bilgi BacaAhmet Dirican
Dec 10, 2013·Diseases of the Colon and Rectum·Howard RossUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
Mar 6, 2016·European Journal of Gastroenterology & Hepatology·George Dafnis
Jul 15, 2015·Diseases of the Colon and Rectum·Gianluca Pellino, Francesco Selvaggi
Oct 22, 2016·World Journal of Surgery·Christian Fredrik RushfeldtTom Wilsgaard
Nov 5, 2019·The Surgical Clinics of North America·Nicholas P McKenna, Amy L Lightner
Aug 11, 2021·World Journal of Emergency Surgery : WJES·Federico CoccoliniFausto Catena

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