Effect of high-frequency chest wall oscillation on the central and peripheral distribution of aerosolized diethylene triamine penta-acetic acid as compared to standard chest physiotherapy in cystic fibrosis

Chest
Steven W StitesBrian Becker

Abstract

High-frequency chest wall oscillation (HFCWO) has been shown to be as effective as standard chest physiotherapy (SCPT) for removal of pulmonary secretions as well as increasing FEV(1) in cystic fibrosis (CF) patients. Patients using HFCWO often administer aerosolized medications simultaneously, reducing time required for daily care. While peripheral pulmonary distribution of tracer in normal subjects has been shown to be unaffected by HFCWO, this has not been studied in CF patients. We evaluated distribution of aerosolized (99m)Tc diethylene triamine penta-acetic acid (DTPA) administered simultaneously with HFCWO and compared this with DTPA aerosolized after SCPT. Ten CF patients, ages 22 to 38 years, with moderate-to-severe obstructive disease were studied in a crossover design after documentation of stable lung function. (133)Xe was administered to delineate total lung volume. DTPA was aerosolized (Pari LC Plus nebulizer and Pulmo-Aide compressor; Pari Respiratory Equipment Inc.; Richmond, VA) to delineate airway deposition. The central to peripheral deposition ratio (C/P ratio) of each lung was analyzed in each study group. Central regions were represented by the inner one third of the (133)Xe scan as demonstrated in previou...Continue Reading

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Citations

Nov 12, 2013·Paediatric Respiratory Reviews·S RandS A Prasad
Mar 13, 2012·Revue des maladies respiratoires·G ReychlerP Lebecque
May 31, 2007·Pediatric Pulmonology·Lianne J van der GiessenHarm A W M Tiddens
Apr 19, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Brenda M ButtonAnne E Holland
Oct 29, 2008·Clinical Rehabilitation·W Darlene ReidJean Crowe
Dec 22, 2015·The Cochrane Database of Systematic Reviews·Louise Warnock, Alison Gates
May 1, 2020·The Cochrane Database of Systematic Reviews·Lisa Morrison, Stephanie Milroy
Jan 28, 2005·The Cochrane Database of Systematic Reviews·E MainC Schans
May 5, 2017·The Cochrane Database of Systematic Reviews·Lisa Morrison, Stephanie Innes

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